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Magnetic resonance imaging showed bilateral, symmetrical abnormalities centred on the lentiform nuclei. Metformin was withheld and signs and symptoms quickly resolved. We hypothesise that metformin may cause thiamine deficiency in patients with end\u2010stage renal failure resulting in a specific metabolic encephalopathy.<\/jats:p>","DOI":"10.1111\/imj.13693","type":"journal-article","created":{"date-parts":[[2018,2,7]],"date-time":"2018-02-07T23:20:15Z","timestamp":1518045615000},"page":"194-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metformin\u2010induced encephalopathy: the role of thiamine"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5928-4912","authenticated-orcid":false,"given":"Caoimhe","family":"McGarvey","sequence":"first","affiliation":[{"name":"Department of Neurology Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Franconi","sequence":"additional","affiliation":[{"name":"Department of Neurology Royal Perth Hospital  Perth 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