{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:54:21Z","timestamp":1782932061184,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T00:00:00Z","timestamp":1525219200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Semi\u2010quantitative wide\u2010field nailfold capillaroscopy (NFC) is a simple technique with proven utility in the early diagnosis of systemic sclerosis (SSc). Its role in prognosis, however, remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the possible utility of NFC in predicting survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SSc listed on the South Australian Scleroderma Register (SASR) with prior NFC performed at Flinders Medical Centre from 1991 to 2015 were included in this study. Baseline demographic data, diagnosis, scleroderma antibody status and mortality status were also collected for each patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort consisted of 99 patients with limited cutaneous SSc, 30 patients with diffuse cutaneous SSc and 23 with an overlap scleroderma syndrome. Fifty\u2010six patients died during the period of study (censured end June 2015).<\/jats:p><jats:p>Patients with diffuse scleroderma had significantly greater capillary dropout compared with limited and overlap scleroderma (<jats:italic>P<\/jats:italic> &lt; 0.001). In univariate analysis, both capillary dropout scores (log\u2010rank <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> = 8.75, <jats:italic>P<\/jats:italic> = 0.003) and antibody status (log\u2010rank <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup> = 13.94, <jats:italic>P<\/jats:italic> = 0.003) were associated with mortality. ANOVA showed a significant association between antibody status and capillary dropout (<jats:italic>P<\/jats:italic> &lt; 0.001). In Cox regression, adjustment for capillary dropout attenuated the impact of autoantibody group on survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nailfold capillary dropout was significantly associated with mortality and the severity of dropout attenuates survival dictated by antibody status. Together these observations support the hypothesis that capillary dropout is on the causal pathway between induction of scleroderma associated autoantibodies and mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13745","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T10:16:45Z","timestamp":1516789005000},"page":"517-523","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The role of nailfold capillary dropout on mortality in systemic sclerosis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2975-176X","authenticated-orcid":false,"given":"Joanna","family":"Tieu","sequence":"first","affiliation":[{"name":"Rheumatology Unit Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Hakendorf","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Woodman","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Patterson","sequence":"additional","affiliation":[{"name":"Immunology Department Flinders Medical Centre and Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Walker","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Flinders Medical Centre  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4330-6398","authenticated-orcid":false,"given":"Peter","family":"Roberts\u2010Thomson","sequence":"additional","affiliation":[{"name":"Immunology Department Flinders Medical Centre and Flinders University  Adelaide South Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.104"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1445-5994.2001.00048.x"},{"key":"e_1_2_7_4_1","first-page":"1573","article-title":"Criteria for the classification of early systemic sclerosis","volume":"28","author":"LeRoy EC","year":"2001","journal-title":"J Rheumatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2011.01688.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2010.02281.x"},{"key":"e_1_2_7_7_1","first-page":"103","article-title":"Nailfold capillaroscopy abnormalities as predictors of mortality in patients with systemic sclerosis","volume":"31","author":"Kayser 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