{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:42:58Z","timestamp":1790379778235,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,8]],"date-time":"2018-07-08T00:00:00Z","timestamp":1531008000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Henoch\u2010Schonlein purpura (HSP) is a rare, typically self\u2010limited, multi\u2010organ vasculitis. Cardiac involvement with HSP carries high morbidity and mortality, thus requiring early aggressive immunosuppressive therapy. We report a case of HSP complicated with acute systolic left ventricular (LV) dysfunction, symptomatic sinus bradycardia and high\u2010grade atrio\u2010ventricular (AV) heart block. Cyclophosphamide, a commonly used agent in HSP, was contraindicated due to the patient's presentation with acute renal failure. Treatment with monoclonal antibody rituximab and corticosteroids was initiated with an improvement in and resolution of LV systolic dysfunction, sinus bradycardia and AV block. We believe this is the first published report on rituximab treatment in HSP with cardiac involvement manifesting with severe LV systolic dysfunction, sinus bradycardia and high\u2010grade AV block.<\/jats:p>","DOI":"10.1111\/imj.13948","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T01:10:35Z","timestamp":1531098635000},"page":"868-871","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Resolution of sinus bradycardia, high\u2010grade heart block, and left ventricular systolic dysfunction with rituximab therapy in Henoch\u2010Schonlein purpura"],"prefix":"10.1111","volume":"48","author":[{"given":"Mikhail","family":"Torosoff","sequence":"first","affiliation":[{"name":"Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2134-5158","authenticated-orcid":false,"given":"Thomas","family":"Breen","sequence":"additional","affiliation":[{"name":"Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Balulad","sequence":"additional","affiliation":[{"name":"Mount Sinai Hospital  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh","family":"Padala","sequence":"additional","affiliation":[{"name":"Virginia Commonwealth University Medical Center  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radmila","family":"Lyubarova","sequence":"additional","affiliation":[{"name":"Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Tan","sequence":"additional","affiliation":[{"name":"Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Albany Medical Center  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,8]]},"reference":[{"key":"e_1_2_3_2_1","first-page":"405","article-title":"Henoch\u2010Schonlein purpura: a review","volume":"58","author":"Kraft DM","year":"1998","journal-title":"Am Fam Physician"},{"key":"e_1_2_3_3_1","first-page":"2797","volume-title":"Harrison's Principles of Internal Medicine","author":"Longo DL","year":"2012"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11279-7"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322008000200018"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1476-7961-9-9"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70344-1"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.04.017"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.5.4.336"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01061.x"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.57.668.390"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.3.497"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.5.e69"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(84)90390-9"},{"key":"e_1_2_3_15_1","first-page":"273","article-title":"A case of Sch\u00f6nlein\u2010Henoch purpura with myocardial complications","volume":"39","author":"Satoh M","year":"1991","journal-title":"Kokyu To Junkan"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0094-3"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-005-0032-0"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002662"},{"key":"e_1_2_3_19_1","first-page":"2788","volume-title":"Harrison's Principles of Internal Medicine","author":"Longo DL","year":"2012"},{"key":"e_1_2_3_20_1","unstructured":"Merchan J.Chemotherapy\u2010related nephrotoxicity and dose modification in patients with renal insufficiency. UpToDate. 2017 [cited 2017 Mar]. Available from URL:http:\/\/www.uptodate.com\/contents\/chemotherapy-related-nephrotoxicity-and-dose-modification-in-patients-with-renal-insufficiency"},{"key":"e_1_2_3_21_1","volume-title":"Drug Prescribing in Renal Failure: Dosing Guidelines for Adults and Children","author":"Aronoff GM","year":"2007"},{"key":"e_1_2_3_22_1","unstructured":"Rituximab: Drug Information. UpToDate. 2017 [cited 2017 Mar]. Available from URL:https:\/\/www-uptodate-com.elibrary.amc.edu\/contents\/rituximab-drug-information?source=search_result&search=rituximab&selectedTitle=1~150"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24434"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40339"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.13948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.13948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T23:36:20Z","timestamp":1694993780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.13948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/imj.13948"],"URL":"https:\/\/doi.org\/10.1111\/imj.13948","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"2017-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}