{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:14:40Z","timestamp":1790122480353,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Procalcitonin (PCT) and C\u2010reactive protein (CRP) are used most widely in the diagnosis\/treatment of bacterial infections. These are not infection\u2010specific and may also show increases in other inflammation\u2010causing cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To establish a new cut\u2010off value for PCT and CRP to eliminate confusion in the diagnosis and treatment of bacterial infections in haemodialysis (HD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1110 patients, 802 with undocumented infection and 308 with documented infection, was included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 802 patients with undocumented infection had a mean CRP value of 12.2 \u00b1 9.6 mg\/dL and a mean PCT value of 0.51 \u00b1 0.96 ng\/mL and the 308 patients with documented infection had a mean CRP value of 125.9 \u00b1 83.3 mg\/dL and a mean PCT value of 13.9 \u00b1 26.9 ng\/mL at the time of admittance. In HD patients, the cut\u2010off values for CRP was determined as 19.15 mg\/dL and for PCT as 0.685 ng\/mL in the presence of infection. The use of these two parameters in combination (CRP \u226519.15 mg\/dL and PCT \u2265 0.685 ng\/mL) was found to have 95% positive predictive value (PPV) and 93% negative predictive value (NPV) for the diagnosis of infectious diseases in HD patients. When CRP \u2265100 mg\/dL and PCT \u22655 ng\/mL, this was found to have 100% PPV and 94% NPV for the diagnosis of sepsis in HD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We specified PCT and CRP cut\u2010off values with high PPV and NPV for revealing the presence of bacterial infection and sepsis in HD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13952","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T09:27:01Z","timestamp":1525253221000},"page":"1222-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["How should procalcitonin and C\u2010reactive protein levels be interpreted in haemodialysis patients?"],"prefix":"10.1111","volume":"48","author":[{"given":"Nazlim A.","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Infectious Disease and Clinical Microbiology Selcuk University Faculty of Medicine  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