{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:07:31Z","timestamp":1784592451740,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T00:00:00Z","timestamp":1538611200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adverse drug reaction (ADR) is a leading but under\u2010recognised cause of illness, particularly in frail subjects with multiple comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the frequency, patterns and outcomes of ADR as a cause of hospitalisation in elderly patients admitted to an internal medicine ward.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective observational study including every patient aged over 65 years who was admitted to our department during a 12\u2010month period. Patients admitted to short\u2010stay (&lt;24 h) observation unit were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ADR accounted for 106 of total 1750 recorded admissions, which constituted a proportion of 6.1% (95% confidence interval 5.0\u20137.3%). The median age of patients was 83.5 (78.0\u201387.0) years and 56.6% were on polypharmacy. A total of 170 ADR was recorded with 45.3% of subjects experiencing concomitantly more than one ADR from a single molecule. Diuretics were the most commonly imputed molecules (30 events, 17.6%), followed by antithrombotics (25 events, 14.7%) and central nervous system\u2010active drugs (16 events, 9.4%). Interactions were judged responsible for 39 cases of ADR (36.8%). An unfavourable outcome was observed in about one\u2010third of patients (37.7%). Among those subjects, 11 (10.4%) died and 29 (27.4%) had residual disability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ADR are a common cause of hospital admission in elderly patients and are often associated with adverse outcomes. Our data underline the need of appropriate strategies aimed at identifying high\u2010risk patients and avoiding potentially preventable drug toxicities.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13961","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T08:19:55Z","timestamp":1525853995000},"page":"1192-1197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Hospitalisation and morbidity due to adverse drug reactions in elderly patients: a single\u2010centre study"],"prefix":"10.1111","volume":"48","author":[{"given":"Silvia","family":"Ognibene","sequence":"first","affiliation":[{"name":"Department of Internal Medicine \u2018C. 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