{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:41:07Z","timestamp":1784673667314,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,9,4]],"date-time":"2018-09-04T00:00:00Z","timestamp":1536019200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Chang Gung Memorial Hospital Linkou Medical Center","award":["grant support for this research (CMRPG3F0851)."],"award-info":[{"award-number":["grant support for this research (CMRPG3F0851)."]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The association between the use of angiotensin\u2010converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) and mortality in end\u2010stage renal disease (ESRD) patients lacks sufficient evidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the efficacy of ACEI and ARB in ESRD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This nationwide retrospective cohort study using data from the Taiwan National Health Insurance Research Database enrolled ESRD patients from January 1997 to December 2011. Propensity score matching provided two study groups (ACEI\/ARB users vs non\u2010users), balanced in sample size, with similar comorbidities and prescriptions. These patients were followed up from the first date of receiving dialysis until mortality, 5 years or 31 December 2013 (whichever came first). We analysed the association of the use of ACEI or ARB with cardiovascular (CV) death and all\u2010cause mortality in patients with ESRD using the Kaplan\u2013Meier method and time\u2010dependent Cox models, with a robust sandwich variance method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After propensity score matching, all characteristics of the user of ACEI or ARB (<jats:italic>n<\/jats:italic> = 17\u2009280) and non\u2010user (<jats:italic>n<\/jats:italic> = 17\u2009280) groups were appropriately balanced (<jats:italic>P<\/jats:italic> &gt; 0.05). In the Cox proportional hazards model, the user group exhibited lower CV death and all\u2010cause mortality with adjusted hazard ratios and 95% CI of 0.58 (0.55\u20130.62) and 0.47 (0.46\u20130.49) than the non\u2010user group did. Furthermore, the association of ACEI\/ARB use with low mortality risk was observed in all examined subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large\u2010scale, population\u2010based cohort study, ESRD patients using ACEI\/ARB had a lower risk of CV death and all\u2010cause mortality than non\u2010users did.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.13971","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T07:29:35Z","timestamp":1527578975000},"page":"1123-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["End\u2010stage renal disease patients using angiotensin\u2010converting enzyme inhibitors and angiotensin receptor blockers may reduce the risk of mortality: a Taiwanese Nationwide cohort study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-2100","authenticated-orcid":false,"given":"Hsin\u2010Fu","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Cardiology, Chang Gung Memorial Hospital Chang Gung University  Linkou Taiwan"},{"name":"Graduate Institute of Clinical Medical Sciences, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai\u2010Chu","family":"See","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Biostatistics Core Laboratory, Molecular Medicine Research Center Chang Gung University  Taoyuan Taiwan"},{"name":"Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine Chang Gung Memorial Hospital  Linkou 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