{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:24:56Z","timestamp":1789802696618,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NHMRC Centre of Research Excellence in Medicines and Ageing (CREMA) Small Project Grants","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adverse drug reactions (ADR) are severe problems in global public health, and result in high mortality and morbidity. Various trends of ADR\u2010related hospitalisations have been studied in many countries, while estimates of the trends in Australia are limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To examine trends in ADR\u2010related hospitalisations in New South Wales (NSW).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were extracted from the Admitted Patient Data Collection, a census of hospital separations in NSW. We estimated age\u2010adjusted rates of ADR\u2010related hospitalisation between 1 July 2001 and 30 June 2014 and rates by patient characteristics, main therapeutic medication groups and clinical condition groups that warranted the hospitalisation. We used the percentage change annualised estimator to evaluate rates over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 315\u2009274 NSW residents admitted for urgent care of ADR was identified. The age\u2010adjusted rates of ADR\u2010related hospitalisations nearly doubled and increased by 5.8% (95% CI: 5.0\u20136.6%)\n                      <jats:italic>per annum<\/jats:italic>\n                      , with an in\u2010hospital death rate increase of 2.4% (1.6\u20133.3%). Agranulocytosis (2.7%), nausea and vomiting (2.4%) and heart failure (2.4%) were the most common conditions that led to ADR\u2010related hospitalisations over 13 years, with acute renal failure (1.4%) recently emerging as the leading adverse condition. Participants aged between 65 and 84 years accounted for nearly half of ADR hospitalisations (45.6%), with age\u2010adjusted rate increasing from 103.9 in 2001\u20132002 to 189.0 per 100\u2009000 NSW residents in 2013\u20132014. Anticoagulants (13.5%) were the most common medications contributing to ADR\u2010related hospitalisation, followed by opioid analgesics (9.6%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ADR\u2010related hospitalisation remains a population health burden, with significant increase over time. The findings call for continuing efforts to prevent ADR, especially among high\u2010risk populations, such as older people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.14134","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T09:48:59Z","timestamp":1538732939000},"page":"84-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Trends in adverse drug reaction\u2010related hospitalisations over 13 years in New South Wales, Australia"],"prefix":"10.1111","volume":"49","author":[{"given":"Hanwen","family":"Zhang","sequence":"first","affiliation":[{"name":"Research School of Population Health Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3622-2265","authenticated-orcid":false,"given":"Wei","family":"Du","sequence":"additional","affiliation":[{"name":"Research School of Population Health Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-3401","authenticated-orcid":false,"given":"Danijela","family":"Gnjidic","sequence":"additional","affiliation":[{"name":"Sydney Pharmacy School and Charles Perkins Centre University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanley","family":"Chong","sequence":"additional","affiliation":[{"name":"South Western Sydney Local Health District and South Western Sydney Clinical School University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Glasgow","sequence":"additional","affiliation":[{"name":"Research School of Population Health Australian National University  Canberra Australian Capital Territory Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzg085"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.15.1200"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.329.7456.15"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7241.1036"},{"key":"e_1_2_7_6_1","volume-title":"Literature Review: Medication Safety in Australia","author":"Australian Commission on Safety and Quality in Health Care","year":"2013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/AH12027"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.03064.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-10-287"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphs.12160"},{"key":"e_1_2_7_11_1","first-page":"9","article-title":"Trends in hospital admissions for adverse drug reactions in England: analysis of national hospital episode statistics 1998\u20132005","volume":"7","author":"Patel H","year":"2007","journal-title":"Br J Clin Pharmacol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.4184"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2005.tb06698.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-017-0140-y"},{"key":"e_1_2_7_15_1","unstructured":"Australian Bureau of Statistics. 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