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Fifty\u2010five (61.1%) of the 90 subjects tested had a history consistent with an IgE\u2010mediated reaction, of whom 24 (43.6%) were proven to be allergic to their index cephalosporin. Twenty (83.3%) of the 24 were allergic only to their index cephalosporin. Of the four remaining subjects, two were co\u2010sensitised to another beta\u2010lactam with a similar side chain, while the other two had no specific cross\u2010reactivity pattern. Major and minor penicillin determinants were negative for all cephalosporin\u2010allergic individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our cohort, cephalosporin allergy does not appear to be a class effect, with most cases found allergic only to their index cephalosporin. Co\u2010sensitisation to other cephalosporins or penicillins was uncommon, and when it occurred, was usually consistent with side chain cross\u2010reactivity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.14229","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T22:42:42Z","timestamp":1548283362000},"page":"985-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Immediate cephalosporin allergy"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2224-6250","authenticated-orcid":false,"given":"Carlo","family":"Yuson","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Allergy, Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimti","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy, 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