{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:38:44Z","timestamp":1782949124682,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T00:00:00Z","timestamp":1575504000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERCV"],"award-info":[{"award-number":["CIBERCV"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Medical therapy could improve the prognosis of real\u2010life patients discharged after a heart failure (HF) hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the impact of discharge HF treatment on mortality and readmissions in different left ventricular ejection fraction (LVEF) groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre prospective registry in 20 Spanish hospitals. Patients were enrolled after a HF hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1831 patients was included (583 (31.8%) HF with reduced ejection fraction (HFrEF); 227 (12.4%) HF with midrange ejection fraction (HFmrEF); 610 (33.3%) HF with preserved ejection fraction (HFpEF), and 411 (22.4%) with unknown LVEF). Angiotensin\u2010converting enzyme (ACE) inhibitors\/angiotensin II receptor blockers (ARB) at discharge were independently associated with a reduction in: (i) all\u2010cause mortality: hazard ratio (HR) 0.55, 95% confidence interval (CI) 0.41\u20130.74, <jats:italic>P<\/jats:italic> &lt; 0.001, with a similar effect in the four groups; (ii) mortality due to refractory HF HR 0.45, 95% CI 0.29\u20130.64, <jats:italic>P<\/jats:italic> &lt; 0.001, with a similar effect in the three groups with known LVEF; (iii) mortality\/HF admissions (HR 0.61; 95% CI: 0.50\u20130.74), more evident in HFrEF (HR 0.54; 95% CI: 0.38\u20130.78) compared with HRmEF (HR 0.64; 95% CI 0.40\u20131.02), or HFpEF (HR 0.70; 95% CI 0.53\u20130.92). In patients with HFrEF triple therapy (ACE inhibitor\/ARB\u2009+\u2009beta blocker\u2009+\u2009mineralocorticoid receptor antagonist) was associated with the lowest mortality risk (HR 0.21; 95% CI: 0.08\u20130.57, <jats:italic>P<\/jats:italic> = 0.002) compared with patients that received none of these drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Discharge treatment with ACE inhibitor\/ARB after a HF hospitalisation is associated with a reduction in all\u2010cause and refractory HF mortality, irrespective of LVEF.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.14289","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T00:11:46Z","timestamp":1553040706000},"page":"1505-1513","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Discharge treatment with angiotensin\u2010converting enzyme inhibitor\/angiotensin receptor blocker after a heart failure hospitalisation is associated with a better prognosis irrespective of left ventricular ejection fraction"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-9788","authenticated-orcid":false,"given":"Lourdes","family":"Vicent","sequence":"first","affiliation":[{"name":"Cardiology Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERCV  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cinca","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital de la Santa Creu i Sant Pau, CIBERCV  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Vazquez\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Cardiology Department Puerta del Mar University Hospital  C\u00e1diz Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 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