{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:50:10Z","timestamp":1777899010240,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,9]],"date-time":"2020-02-09T00:00:00Z","timestamp":1581206400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Townsville Hospital is a tertiary hospital in North Queensland with one of the largest regional transplant centres in Australia, performing primarily autologous haemopoietic stem cell transplants (HSCT) for various haematological malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This single\u2010centre, retrospective, observational study aims to describe the activity and outcomes of autologous HSCT at The Townsville Hospital between 2003 and 2017 to verify safety standards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient\u2010level data were collected, including demographics, frequency and indication for transplant, conditioning, current clinical status and cause of death. Key outcomes included overall survival, non\u2010relapse mortality, incidence of therapy\u2010related neoplasm and causes of death. Progression\u2010free survival in the multiple myeloma (MM) subgroup was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 319 autologous HSCT in 286 patients, with a median age of 58 years (range 14\u201371 years); 62% of patients were male. Indications for transplantation were: MM 53.7%, non\u2010Hodgkin lymphoma 29.4%, Hodgkin lymphoma 5.0% and other 11.9%. Causes of death were: disease progression\/relapse (65.2%), second malignancy (17.0%), infection (9.8%) and other (8.0%). Non\u2010relapse mortality was 1.2% (95% confidence interval 0.4\u20133.0) and 3.2% (1.7\u20135.7) at 100 days and 1 year, respectively, post\u2010HSCT. Overall survival at 2 years was 81.0% (73.8\u201386.4) for MM and 69.6% (58.8\u201378.1) for non\u2010Hodgkin lymphoma. The median progression\u2010free survival in the MM cohort was 3.3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Townsville Hospital transplant centre provides an important transplant service in regional Queensland, with outcomes comparable to national data. We reported a relatively high rate of second malignancy as a cause of death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.14395","type":"journal-article","created":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T13:06:31Z","timestamp":1560171991000},"page":"214-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A 14\u2010year retrospective analysis of indications and outcomes of autologous haemopoietic stem cell transplantation in regional Queensland: a single\u2010centre experience"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3886-968X","authenticated-orcid":false,"given":"Elizabeth M.","family":"Hamilton","sequence":"first","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"},{"name":"School of Medicine Griffith University  Gold Coast Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3881-5681","authenticated-orcid":false,"given":"Karthik D.","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"},{"name":"School of Medicine University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkat N.","family":"Vangaveti","sequence":"additional","affiliation":[{"name":"College of Medicine and Dentistry James Cook University  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew D.","family":"McCutchan","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jodie L.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Birchley","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Casey","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"McNamara","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hock C.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward S.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Hodges","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation The Townsville Hospital  Townsville Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian M.","family":"Irving","sequence":"additional","affiliation":[{"name":"Icon Group  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.05.035"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.4600"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.18"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu264"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(16)00036-3"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.2719"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2015.09.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.763396"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2011.08.022"},{"key":"e_1_2_7_11_1","first-page":"28","article-title":"Bone marrow transplant for multiple myeloma: impact of distance from the transplant center","volume":"10","author":"Lipe BC","year":"2012","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_7_12_1","unstructured":"Australian Bureau of Statistics. 2016 Census QuickStats. 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