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She re\u2010presented 6 months later with a fall and had classical signs of subacute combined degeneration of the spinal cord confirmed on nerve conduction studies, as a result of zinc\u2010induced copper deficiency. After 6 months of copper therapy, she made a complete recovery with no residual neurological deficits. Early detection of zinc\u2010induced copper deficiency and stringent follow\u2010up mechanisms are crucial. Early initiation of copper replacement may both limit and completely reverse neurological deficits.<\/jats:p>","DOI":"10.1111\/imj.14694","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T02:30:15Z","timestamp":1579055415000},"page":"121-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Wilson disease: copper deficiency and iatrogenic neurological complications with zinc therapy"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8684-4172","authenticated-orcid":false,"given":"Landy M.","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Medicine Frankston Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel","family":"Ekladious","sequence":"additional","affiliation":[{"name":"Department of Medicine Bunbury Hospital  Bunbury Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6958-5877","authenticated-orcid":false,"given":"Luke","family":"Wheeler","sequence":"additional","affiliation":[{"name":"University of Notre Dame  Fremantle Western Australia Australia"},{"name":"Department of Medicine Northern Adelaide Local Health Unit  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrazak A.","family":"Mohamad","sequence":"additional","affiliation":[{"name":"Department of Medicine Hunter New England Area Health  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,14]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5511-x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.12.095"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60196-2"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pjnns.2014.05.002"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6963-6"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2012.03.008"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132644.52613.FA"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3407-5"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2014-202837"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2008.01050.x"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12020"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563215595429"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.188896"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21425"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2010.07.018"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.25146"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.14694","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:50:20Z","timestamp":1694137820000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.14694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/imj.14694"],"URL":"https:\/\/doi.org\/10.1111\/imj.14694","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}