{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:09:47Z","timestamp":1790104187070,"version":"4.0.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1083090"],"award-info":[{"award-number":["1083090"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1090440"],"award-info":[{"award-number":["1090440"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The rate of hospital admissions for cirrhosis increased 1.3\u2010fold during 2008\u20132016 in Queensland. Alcohol misuse was a contributing factor for cirrhosis in 55% of admissions and 40% of patients had at least one comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the temporal change in aetiology of liver disease and presence of comorbidity in patients admitted with cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Population\u2010based retrospective cohort study of all people treated in hospital for cirrhosis (10\u2009254 patients) in Queensland during 2008\u20132016. Data were sourced from Queensland Hospital Admitted Patient Data Collection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The commonest aetiology was alcohol (49.5%), followed by cryptogenic (unspecified cirrhosis; 28.5%), hepatitis C virus (19.3%), non\u2010alcoholic fatty liver disease (NAFLD)\/non\u2010alcoholic steatohepatitis (NASH) (4.8%) and hepatitis B virus (HBV) (4.3%). The prevalence of alcohol\u2010related (<jats:italic>P<\/jats:italic> =\u20090.41) and hepatitis C virus (<jats:italic>P<\/jats:italic> =\u20090.08) remained stable between 2008\u20132010 and 2014\u20132016, that of NAFLD\/NASH, cryptogenic and HBV\u2010cirrhosis increased by 67% (<jats:italic>P<\/jats:italic> &lt;\u20090.00001), 27% (<jats:italic>P<\/jats:italic> &lt;\u20090.00001) and 20% (<jats:italic>P<\/jats:italic> =\u20090.00019), respectively; 41.1% of patients had at least one comorbidity. The prevalence of type 2 diabetes nearly doubled (from 13.7% to 25.4%; <jats:italic>P<\/jats:italic> &lt;\u20090.00001) between 2008\u20132010 and 2014\u20132016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alcohol misuse was the most important aetiology. The importance of NAFLD\/NASH, cryptogenic and HBV\u2010cirrhosis and the burden of comorbidity increased during 2008\u20132016. Ongoing alcohol misuse and the increasing prevalence of NAFLD\/NASH, cryptogenic cirrhosis and comorbid type 2 diabetes among admissions for cirrhosis has implications for public health interventions to reduce the burden of unhealthy lifestyle and metabolic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.14809","type":"journal-article","created":{"date-parts":[[2020,2,25]],"date-time":"2020-02-25T16:29:00Z","timestamp":1582648140000},"page":"691-698","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Changing prevalence of aetiological factors and comorbidities among Australians hospitalised for cirrhosis"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8823-3006","authenticated-orcid":false,"given":"Patricia C.","family":"Valery","sequence":"first","affiliation":[{"name":"Population Health Department QIMR Berghofer Medical Research Institute  Brisbane Queensland 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