{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:25:26Z","timestamp":1779315926902,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyponatraemia is common in patients with acute heart failure (HF). <jats:bold>Aims<\/jats:bold>: To determine the impact of sodium disturbances on mortality and readmissions in HF with reduced left ventricular ejection fraction (HFrEF), preserved ejection fraction (HFpEF) and mid\u2010range ejection fraction (HFmrEF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a prospective multicentre consecutive registry in 20 hospitals, including patients admitted due to acute HF in cardiology departments. Sodium &lt;135\u2009mmol\/L was considered hyponatraemia, &gt;145\u2009mmol\/L hypernatraemia and 135\u2013145\u2009mmol\/L normal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1309 patients was included. Mean age was 72.0 \u00b1\u200911.9\u2009years, and 810 (61.9%) were male. Mean serum sodium level was 138.6 \u00b1\u20094.7\u2009mmol\/L at hospital admission and 138.1 \u00b1\u20094.1\u2009mmol\/L at discharge. The evolution of sodium levels was: normal\u2010at\u2010admission\/normal\u2010at\u2010discharge 941 (71.9%), abnormal\u2010at\u2010admission\/normal\u2010at\u2010discharge 127 (9.7%), normal\u2010at\u2010admission\/abnormal\u2010at\u2010discharge 155 (11.8%) and abnormal\u2010at\u2010admission\/abnormal\u2010at\u2010discharge 86 (6.6%). Hyponatraemia at discharge was more common in HFrEF (109 (20.7%)) than in HFpEF (79 (13.9%)) and HFmrEF (27 (12%)), P\u00a0=\u00a00.003. The prevalence of hypernatraemia at discharge was similar in the three groups: HFrEF (10 (1.9%)), HFpEF (12 (2.1%)) and HFmrEF (4 (1.9%)), P\u00a0=\u00a00.96. In multivariate analysis, abnormal sodium concentrations at hospital admission (hazard ratio (HR) 1.42, 95% confidence interval (CI) 1.15\u20131.76, P\u00a0=\u00a00.001) and discharge (HR 1.33, 95% CI 1.08\u20131.64, P\u00a0=\u00a00.007) were both independently associated with increased mortality and readmissions at 12 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hyponatraemia and hypernatraemia at admission and discharge predict a poor outcome in patients with acute HF regardless of left ventricular ejection fraction. Hyponatraemia at discharge is more frequent in HFrEF than in the other groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.14836","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T09:00:34Z","timestamp":1585731634000},"page":"930-938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic impact of hyponatraemia and hypernatraemia at admission and discharge in heart failure patients with preserved, mid\u2010range and reduced ejection fraction"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7914-9788","authenticated-orcid":false,"given":"Lourdes","family":"Vicent","sequence":"first","affiliation":[{"name":"Cardiology Department Hospital Universitario 12 de Octubre  Madrid Spain"},{"name":"Cardiology Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERCV  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Alvarez\u2010Garcia","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital de la Santa Creu i Sant Pau, CIBERCV  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Gonzalez\u2010Juanatey","sequence":"additional","affiliation":[{"name":"Cardiology and Coronary Care Unit Department Complexo Hospitalario Universitario de Santiago de Compostela, CIBERCV  A Coru\u00f1a Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Rivera","sequence":"additional","affiliation":[{"name":"Cardiology Department University Hospital La Fe  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Segovia","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Universitario Puerta de Hierro Majadahonda, CIBERCV  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Worner","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Universitari Arnau de Vilanova, IRBLLEIDA  Lleida Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Bover","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico San Carlos  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domingo","family":"Pascual\u2010Figal","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Cl\u00ednico Universitario Virgen de la Arrixaca  El Palmar Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Cardiology Department Puerta del Mar University Hospital  C\u00e1diz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Cinca","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital de la Santa Creu i Sant Pau, CIBERCV  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Fernandez\u2010Aviles","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERCV  Madrid Spain"},{"name":"Universidad Complutense  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Martinez\u2010Sell\u00e9s","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital General Universitario Gregorio Mara\u00f1\u00f3n, CIBERCV  Madrid Spain"},{"name":"Universidad Complutense  Madrid Spain"},{"name":"Universidad Europea  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.15420\/cfr.2016:25:2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-015-9482-y"},{"key":"e_1_2_8_5_1","first-page":"485","article-title":"Fluid and electrolyte disorders in congestive heart failure","volume":"14","author":"Oster JR","year":"1994","journal-title":"Semin Nephrol"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000165065.82609.3D"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr086"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.73.2.257"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs099"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq426"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.06.013"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.945"},{"key":"e_1_2_8_13_1","first-page":"338","article-title":"Mid\u2010range ejection fraction does not permit risk stratification among patients hospitalized for heart failure","volume":"70","author":"Gomez\u2010Otero I","year":"2017","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-2-199601150-00002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-7133.2010.00206.x"},{"key":"e_1_2_8_16_1","first-page":"338","article-title":"Mid\u2010range ejection fraction does not permit risk stratification among patients hospitalized for heart failure","volume":"70","author":"G\u00f3mez\u2010Otero I","year":"2017","journal-title":"Rev Esp Cardiol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22979"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfs115"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.111.961011"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/732746"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005261"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2014.06.177"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-017-0598-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.03.017"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.08.004"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2011.01.081"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.14785"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2005.09.001"},{"key":"e_1_2_8_29_1","doi-asserted-by":"crossref","unstructured":"Intern Med J 2019 49 Discharge treatment with angiotensin\u2010converting enzymeinhibitor\/angiotensin receptor blocker after a heart failure hospitalisation is associated with a better prognosis irrespective of left ventricular ejection fraction","DOI":"10.1111\/imj.14289"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.14797\/mdcj-11-4-235"},{"key":"e_1_2_8_31_1","first-page":"315","article-title":"Heart failure and electrolyte disturbances","volume":"14","author":"Schwinger RH","year":"1992","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.010"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fimj.14836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14836","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.14836","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.14836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T20:03:30Z","timestamp":1693425810000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.14836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1111\/imj.14836"],"URL":"https:\/\/doi.org\/10.1111\/imj.14836","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2019-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}