{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T11:03:59Z","timestamp":1753182239380,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,21]],"date-time":"2021-06-21T00:00:00Z","timestamp":1624233600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Malignant peritoneal mesothelioma is the most common primary peritoneal neoplasm. The only universally recognised pathological prognostic factor is histopathological subtype. Prognostic markers based on patient features and clinical stages have been disappointing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the prognostic role of several clinicopathological features in a retrospective cohort of 60 patients diagnosed with peritoneal mesothelioma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty patients were centrally collected and were immunohistochemically analysed for the expression of osteopontin (OPN), GLUT1 and Ki\u201067. Labelling was assessed by two pathologists. Complete clinical information and follow\u2010up were obtained from patients' records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>OPN expression was identified in 52 (86.6%) of 60 specimens, and GLUT1 in 39 (65%) of 60 specimens. Univariate Cox regression analysis showed that a lower peritoneal carcinomatosis index (PCI), tumour\u2010directed treatment (chemotherapy or surgery alone or in any combination), lower Ki\u201067, GLUT1 and lower OPN expression had a statistically significant positive effect on overall survival (OS). PCI (hazard ratio (HR) =\u20091.032 (95% confidence interval (CI): 1.000\u20131.067); <jats:italic>P<\/jats:italic> =\u20090.054) and tumour\u2010directed treatment (HR\u00a0=\u00a00.211 (95% CI: 0.104\u20130.430); <jats:italic>P<\/jats:italic> &lt;\u20090.001), Ki\u201067 (HR\u00a0=\u00a022.326 (95% CI: 3.523\u2013141.498); <jats:italic>P<\/jats:italic> =\u20090.003) and OPN (HR\u00a0=\u00a07.268 (95% CI: 1.771\u201329.811); <jats:italic>P<\/jats:italic> =\u20090.009) retained independent prognostic significance in the multivariate analysis, all with a positive effect on OS with the exception of GLUT1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OPN, Ki\u201067, treatment and PCI were independent indicators for OS, and a higher level of OPN expression correlated significantly with poorer OS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.14936","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T13:08:44Z","timestamp":1591621724000},"page":"896-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Osteopontin, <scp>GLUT1<\/scp> and Ki\u201067 expression in malignant peritoneal mesothelioma: prognostic implications"],"prefix":"10.1111","volume":"51","author":[{"given":"Yingying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Yang","sequence":"additional","affiliation":[{"name":"Cangzhou Medical College  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Pathology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-9329","authenticated-orcid":false,"given":"Yufei","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.07.003"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra050152"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2665"},{"key":"e_1_2_6_5_1","first-page":"867","article-title":"Immunobiochemical and molecular biologic characterization of the cell proliferation\u2010associated nuclear antigen that is defined by monoclonal antibody Ki\u201067","volume":"138","author":"Gerdes J","year":"1991","journal-title":"Am J Pathol"},{"key":"e_1_2_6_6_1","first-page":"655","article-title":"Ki\u201067 expression in gastric cancer. 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