{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:27:36Z","timestamp":1770535656463,"version":"3.49.0"},"reference-count":64,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T00:00:00Z","timestamp":1647734400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early, accurate diagnosis of invasive fungal disease (IFD) improves clinical outcomes. 1,3\u2010beta\u2010<jats:sc>d<\/jats:sc>\u2010glucan (BDG) (Fungitell, Associates of Cape Cod, Inc., Falmouth, MA, USA) detection can improve IFD diagnosis but has been unavailable in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess performance of serum BDG for IFD diagnosis in a high\u2010risk Australian haematology population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared the diagnostic value of weekly screening of serum BDG with screening by <jats:italic>Aspergillu<\/jats:italic>s polymerase chain reaction and <jats:italic>Aspergillus<\/jats:italic> galactomannan in 57 at\u2010risk episodes for the diagnosis of IFD (proven, probable, possible IFD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IFD episodes were: proven (<jats:italic>n<\/jats:italic> =\u20094); probable (<jats:italic>n<\/jats:italic> =\u20094); possible (<jats:italic>n<\/jats:italic> =\u200918); and no IFD (<jats:italic>n<\/jats:italic> =\u200931). Using two consecutive BDG results of \u226580 pg\/mL to call a result \u2018positive\u2019, the sensitivity, specificity, positive predictive value and negative predictive value was 37.5%, 64.5%, 23.1% and 80.7% respectively. For invasive aspergillosis, test performance increased to 50%, 90.3%, 57.1% and 87.5% respectively if any two of serum BDG\/<jats:italic>Aspergillus<\/jats:italic> polymerase chain reaction\/galactomannan yielded a \u2018positive\u2019 result. In proven\/probable IFD, five of eight episodes returned a positive BDG result earlier (mean 6.6\u2009days) than other diagnostic tests. False\u2010negative BDG results occurred in three of eight episodes of proven\/probable IFD, and false positive in 10 of 31 patients with no IFD. Erratic patterns of BDG values predicted false positive results (<jats:italic>P<\/jats:italic> =\u20090.03). Using serum BDG results, possible IFD were reassigned to either \u2018no\u2019 or \u2018probable\u2019 IFD in 44% cases. Empiric anti\u2010fungal therapy use may have been optimised by BDG monitoring in 38.5% of courses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The BDG assay can add diagnostic speed and value but was hampered by low sensitivity and positive predictive value in Australian haematology patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15046","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T07:30:46Z","timestamp":1600673446000},"page":"426-435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Introducing 1,3\u2010beta\u2010<scp>d<\/scp>\u2010glucan for screening and diagnosis of invasive fungal diseases in Australian high\u2010risk haematology patients: is there a clinical 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