{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:53:30Z","timestamp":1762642410382,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Among hypertensive patients, the association between treatment with angiotensin\u2010converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) and the clinical severity of COVID\u201019, remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine whether hypertensive patients hospitalised with COVID\u201019 are at risk of worse outcomes if on treatment with ACEI or ARB compared to other anti\u2010hypertensive medications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective study conducted at a single academic medical centre (Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy) from 1 to 31 March 2020. We compared patients on treatment with an ACEI\/ARB (ACEI\/ARB group) to patients receiving other anti\u2010hypertensive medications (No\u2010ACEI\/ARB group). The end\u2010points of the study were the all\u2010cause in\u2010hospital death and the combination of in\u2010hospital death or need for intensive care unit (ICU) admission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample included 166 COVID\u201019 patients; median age was 74\u2009years and 109 (66%) were men. Overall, 111 (67%) patients were taking an ACEI or ARB. Twenty\u2010nine (17%) patients died during the hospital stay, and 51 (31%) met the combined end\u2010point. After adjustment for comorbidities, age and degree of severity at the presentation, ACEI or ARB treatment was an independent predictor neither of in\u2010hospital death nor of the combination of in\u2010hospital death\/need for ICU. No differences were documented between treatment with ACEI compared to ARB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among hypertensive patients hospitalised for COVID\u201019, treatment with ACEI or ARB is not associated with an increased risk of in\u2010hospital death.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15078","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T18:33:20Z","timestamp":1602009200000},"page":"1483-1491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Angiotensin\u2010converting enzyme inhibitors or angiotensin II receptor blockers and prognosis of hypertensive patients hospitalised with COVID\u201019"],"prefix":"10.1111","volume":"50","author":[{"given":"Marcello","family":"Covino","sequence":"first","affiliation":[{"name":"Emergency Department Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2982-3951","authenticated-orcid":false,"given":"Giuseppe","family":"De Matteis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Livia","family":"Burzo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Santoro","sequence":"additional","affiliation":[{"name":"Emergency Department Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariella","family":"Fuorlo","sequence":"additional","affiliation":[{"name":"Emergency Department Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Sabia","sequence":"additional","affiliation":[{"name":"Emergency Department Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Sandroni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Gasbarrini","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario A. Gemelli  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Franceschi","sequence":"additional","affiliation":[{"name":"Emergency Department Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario A. Gemelli  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Gambassi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Fondazione Policlinico Universitario A. Gemelli IRCCS  Rome Italy"},{"name":"Faculty of Medicine and Surgery Universit\u00e0 Cattolica del Sacro Cuore  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"Gemelli Against COVID\u201019 Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"The World Health Organization (WHO) Health Emergency Dashboard.2020[cited 2020 Sep 1]. 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