{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T05:56:10Z","timestamp":1759384570469,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T00:00:00Z","timestamp":1642636800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Free concentrations of highly protein bound hormones, such as cortisol and thyroxine, are unchanged in critical illness despite substantial decreases in total concentration. Total 25\u2010hydroxyvitamin D (25(OH)D) concentration is decreased in critical illness, but the free concentration of 25(OH)D has had less attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare total and calculated free 25(OH)D concentrations in critically ill patients with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this case\u2010control study, 38 patients with critical illness were compared with 68 healthy controls; 25(OH)D was measured by liquid chromatography tandem mass spectrometry (LCMS\/MS) and vitamin D binding protein (VDBP) by direct sandwich enzyme\u2010linked immunosorbent assay. Total and calculated free 25(OH)D concentrations were compared using unpaired <jats:italic>t<\/jats:italic>\u2010tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total 25(OH)D concentrations were significantly lower in critically ill patients than controls (37 (95% confidence interval 31\u201343) vs 57 (53\u201360) nmol\/L). Calculated free concentrations of 25(OH)D were not lower in critically ill patients than healthy controls (26 (22\u201329) vs 19 (18\u201320) pmol\/L).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Calculated free 25(OH)D concentrations are not decreased in critical illness. Measuring total 25(OH)D concentrations in patients with critical illness potentially underestimates vitamin D and overestimates the number of patients who are deficient in vitamin D.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15096","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T12:31:15Z","timestamp":1602419475000},"page":"89-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unbound vitamin D concentrations are not decreased in critically ill patients"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5208-681X","authenticated-orcid":false,"given":"David","family":"Palmer","sequence":"first","affiliation":[{"name":"Department of General Medicine Canterbury District Health Board  Christchurch New 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