{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:20:39Z","timestamp":1761582039494,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aim<\/jats:title><jats:p>Mitral valve prolapse (MVP) is a common disease in women, causing chest pain and palpitation due to structural and functional valve abnormality, and is sometimes associated with gastro\u2010oesophageal reflux disease (GERD). This is a challenging clinical problem in clinical practice and requires targeted diagnostic assessment to identify the underlying causes of the symptoms, because treatment needs to be tailored, according to the causes themselves, to resolve the symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the prevalence of GERD in a population of postmenopausal women affected by MVP and determine if there is any correlation between the two conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The MVP diagnosis was performed using echocardiograpy examination, according to American Society Echocardiography criteria. Two hundred and eighty\u2010nine consecutive MVP women, symptomatic for chest pain and palpitation, were included; 250 consecutive women without MVP, symptomatic for chest pain and palpitation, were the control group (CG). The GERD diagnosis was made according to 2013 American College Gastroenterology criteria; women affected by thyroid disorders, all heart disease, including mitral disease with moderate or severe mitral regurgitation, and gastrointestinal diseases assessed using gastroscopy were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 289 women with MVP, 31 (11%) women were affected by GERD, and among 250 in the CG, 11 (4.4%) women were affected by GERD: Chi\u2010squared 8.1; odds ratio 2.7; <jats:italic>P<\/jats:italic> &lt;\u20090.0044. Twenty\u2010six (9%) women affected by GERD, with MVP, presented with mild mitral regurgitation, and 7 (2.8%) women in the CG presented with mild mitral regurgitation as well: Chi\u2010squared 8.95; odds ratio 3.4; 95% CI, <jats:italic>P<\/jats:italic> &lt;\u20090.0028.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion and conclusions<\/jats:title><jats:p>GERD is relatively common in women with MVP. Moreover, women with MVP are approximately three times more likely to be affected by GERD; the two conditions are correlated in a statistically high significant way. GERD assessment needs to be included into routine follow\u2010up strategies in women with MVP to optimise medical therapy, improvinge symptom relief for better quality of life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15174","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T04:54:06Z","timestamp":1608612846000},"page":"848-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chest pain and palpitations in postmenopausal women with mitral valve prolapse: is there a gastro\u2010oesophageal origin?"],"prefix":"10.1111","volume":"52","author":[{"given":"Maria","family":"Maiello","sequence":"first","affiliation":[{"name":"ASL BRINDISI, Cardiology Equipe, District of Brindisi  Brindisi Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annapaola","family":"Zito","sequence":"additional","affiliation":[{"name":"ASL BRINDISI, Cardiology Equipe, District of Francavilla Fontana  Francavilla Fontana Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annagrazia","family":"Cecere","sequence":"additional","affiliation":[{"name":"Department of Cardiac\u2010Thoracic\u2010Vascular Science and Public Health University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Matteo","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Section, Department of Emergency and Organ Transplantation (DETO) University of Bari  Bari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8285-1623","authenticated-orcid":false,"given":"Pasquale","family":"Palmiero","sequence":"additional","affiliation":[{"name":"ASL BRINDISI, Cardiology Equipe, District of Brindisi  Brindisi 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