{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:22:20Z","timestamp":1785306140608,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Low\u2010dose long\u2010term azithromycin is recommended in clinical practice guidelines for obstructive airway diseases (OAD); however, an optimal therapeutic regimen is not yet established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To understand the patterns of azithromycin use in OAD, characterise the patients who received it and evaluate its safety and efficacy using real\u2010world data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We audited 91 patients who had received azithromycin for at least 4\u2009weeks for the management of asthma, chronic obstructive pulmonary disease (COPD) or non\u2010cystic fibrosis bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age was 65 \u00b1\u200918\u2009years, 60% were female and 48% were ex\u2010smokers. The majority had asthma (75%), either alone (50%) or in combination with COPD (12%) or bronchiectasis (13%). Most (64%) reported cough or sputum at baseline. The most common treatment regimen was azithromycin 250 mg daily (73%) for more than 1 year (57%), with only seven adverse events. There was a significant reduction in the proportions of patients requiring emergency department visits (48% vs 32%; <jats:italic>P<\/jats:italic> &lt;\u20090.001) and hospital admissions (35% vs 31%; <jats:italic>P<\/jats:italic> &lt;\u20090.001) after starting azithromycin. In 88% of cases, physicians favoured the use of azithromycin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Physicians are currently using low\u2010dose azithromycin for a long duration of more than 1 year for the management of OAD. The typical case definition is an older non\u2010smoking adult with persistent asthma, often in combination with another OAD and presenting with bothersome cough or sputum. Azithromycin was well tolerated and led to reduced healthcare utilisation. Further research is required to establish an optimal dosage regimen of azithromycin in OAD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15216","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T08:59:32Z","timestamp":1612429172000},"page":"1016-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patterns of azithromycin use in obstructive airway diseases: a real\u2010world observational study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4182-6821","authenticated-orcid":false,"given":"Dennis","family":"Thomas","sequence":"first","affiliation":[{"name":"Priority Research Centre for Healthy Lungs Hunter Medical Research Institute (HMRI), University of Newcastle  Newcastle New South Wales Australia"},{"name":"Faculty of Health and Medicine University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa M.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs Hunter Medical Research Institute (HMRI), University of Newcastle  Newcastle New South Wales Australia"},{"name":"Faculty of Health and Medicine University of Newcastle  Newcastle New South Wales Australia"},{"name":"Department of Respiratory and Sleep Medicine John Hunter Hospital  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodie L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Priority Research Centre for Healthy Lungs Hunter Medical Research Institute (HMRI), University of Newcastle  Newcastle New South Wales Australia"},{"name":"Faculty of Health and Medicine University of Newcastle  Newcastle New South Wales Australia"},{"name":"Department of Respiratory and Sleep Medicine John Hunter Hospital  Newcastle New 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