{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:30:21Z","timestamp":1762918221253,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Aspirin is routinely prescribed in high\u2010risk pregnancies to prevent pre\u2010eclampsia; however, there is a paucity of data in women with pre\u2010existing diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the efficacy and safety of aspirin in women with pre\u2010existing diabetes in preventing pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of women with pre\u2010existing diabetes who attended antenatal clinics in a tertiary referral hospital between 2013 and 2019 was conducted. Cases were those receiving aspirin prior to 16\u2009weeks, with pre\u2010eclampsia as the primary outcome. The relationship between early pregnancy glycaemic control and pre\u2010eclampsia was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 164 women included in the study, 45 received aspirin. There were no differences in pre\u2010eclampsia (odds ratio (OR) 0.9 (0.3\u20133.0), <jats:italic>P<\/jats:italic> =\u20090.924) or any other measure of placental insufficiency (OR 1.7 (0.7\u20134.3), <jats:italic>P<\/jats:italic> =\u20090.243) between the aspirin and control groups after adjusting for baseline differences. Aspirin therapy was associated with an increased risk of postpartum haemorrhage (PPH) (OR 3.1 (1.1\u20139.1), <jats:italic>P<\/jats:italic> =\u20090.041). The incidence of pre\u2010eclampsia increased stepwise according to early pregnancy HbA1c subgroups of \u22646.0% (<jats:italic>n<\/jats:italic> =\u200947), 6.1\u20137.5% (<jats:italic>n<\/jats:italic> =\u200957) and &gt;\u20097.5% (<jats:italic>n<\/jats:italic> =\u200939), with rates of 0, 12.3 and 20.5% (<jats:italic>P<\/jats:italic> =\u20090.007) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The aspirin group had a higher baseline risk of pre\u2010eclampsia and placental insufficiency, therefore the absence of difference between the groups favoured the efficacy of aspirin. PPH was highlighted as a potential complication of therapy, and early pregnancy HbA1c as a novel risk stratification tool for pre\u2010eclampsia in women with pre\u2010existing diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15257","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T07:56:52Z","timestamp":1614671812000},"page":"1673-1680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aspirin and pre\u2010eclampsia prevention in women with pre\u2010existing diabetes: a retrospective study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2834-2486","authenticated-orcid":false,"given":"Siehoon","family":"Lah","sequence":"first","affiliation":[{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N Wah","family":"Cheung","sequence":"additional","affiliation":[{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Diabetes and Endocrinology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Lee","sequence":"additional","affiliation":[{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Renal Medicine Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Athayde","sequence":"additional","affiliation":[{"name":"Women's and Newborn Health Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Inglis","sequence":"additional","affiliation":[{"name":"Women's and Newborn Health Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suja","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Sydney Medical School The University of Sydney  Sydney New South Wales Australia"},{"name":"Diabetes and Endocrinology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6564"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"e_1_2_7_4_1","first-page":"122","article-title":"Pre\u2010existing diabetes in pregnancy","volume":"41","author":"Padmanabhan S","year":"2016","journal-title":"Minerva Endocrinol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17987-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92207-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60712-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)70225-0"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)34984-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)15268-3"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2018.10.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_7_13_1","unstructured":"GardosiJ FrancisA. 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