{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:22Z","timestamp":1747185442956,"version":"3.40.5"},"reference-count":49,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T00:00:00Z","timestamp":1653955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100015539","name":"Australian Government","doi-asserted-by":"publisher","award":["290465"],"award-info":[{"award-number":["290465"]}],"id":[{"id":"10.13039\/100015539","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with cancer are at high risk for infection, but the epidemiology of healthcare\u2010associated <jats:italic>Staphylococcus aureus<\/jats:italic> bacteraemia (HA\u2010SAB) and <jats:italic>Clostridioides difficile<\/jats:italic> infection (HA\u2010CDI) in Australian cancer patients has not previously been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the cumulative aggregate incidence and time trends of HA\u2010SAB and HA\u2010CDI in a predefined cancer cohort with a mixed statewide patient population in Victoria, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All SAB and CDI events in patients admitted to Victorian healthcare facilities between 1 July 2010 and 31 December 2018 were submitted to the Victorian Healthcare Associated Infection Surveillance System Coordinating Centre. Descriptive analyses and multilevel mixed\u2010effects Poisson regression modelling were applied to a standardised data extract.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 10\u2009608 and 13\u2009118 SAB and CDI events were reported across 139 Victorian healthcare facilities, respectively. Of these, 89 (85%) and 279 (88%) were healthcare\u2010associated in the cancer cohort compared with 34% (3561\/10\u2009503) and 66% (8403\/12\u2009802) in the statewide cohort. The aggregate incidence was more than twofold higher in the cancer cohort compared with the statewide cohort for HA\u2010SAB (2.25 (95% confidence interval (CI): 1.74\u20132.77) vs 1.11 (95% CI: 1.07\u20131.15) HA\u2010SAB\/10\u2009000 occupied bed\u2010days) and threefold higher for HA\u2010CDI (6.26 (95% CI: 5.12\u20137.41) vs 2.31 (95% CI: 2.21\u20132.42) HA\u2010CDI\/10\u2009000 occupied bed\u2010days). Higher quarterly diminishing rates were observed in the cancer cohort than the statewide data for both infections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate a higher burden of HA\u2010SAB and HA\u2010CDI in a cancer cohort when compared with state data and highlight the need for cancer\u2010specific targets and benchmarks to meaningfully support quality improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15301","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T10:48:39Z","timestamp":1616496519000},"page":"1215-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of a Victorian statewide surveillance programme to evaluate the burden of healthcare\u2010associated <i>Staphylococcus aureus<\/i> bacteraemia and <i>Clostridioides difficile<\/i> infection in patients with cancer"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3076-9182","authenticated-orcid":false,"given":"Jake C.","family":"Valentine","sequence":"first","affiliation":[{"name":"National Centre for Infections in Cancer Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Hall","sequence":"additional","affiliation":[{"name":"National Centre for Infections in Cancer Peter MacCallum Cancer Centre  Melbourne Victoria Australia"},{"name":"School of Public Health University of Queensland  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin M.","family":"Verspoor","sequence":"additional","affiliation":[{"name":"National Centre for Infections in Cancer Peter MacCallum Cancer Centre  Melbourne Victoria 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