{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:24:53Z","timestamp":1782552293142,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>While the role of high\u2010flow nasal cannulae (HFNC) in the management of respiratory failure continues to expand, few studies describe its use in acute hypercapnic respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this retrospective study, we assessed the safety and efficacy of HFNC for the treatment of acute hypercapnic respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Admissions with acute hypercapnic respiratory failure to a thoracic medicine unit at a tertiary centre between January and August 2018 were included if treated with either HFNC or non\u2010invasive ventilation (NIV). The primary outcome was post\u2010treatment change in arterial pCO<jats:sub>2<\/jats:sub>. Demographics, comorbidities, length of stay, readmission rate and mortality were also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four patients were identified, comprising 69 presentations grouped according to initial treatment: HFNC (<jats:italic>n<\/jats:italic> =\u200924) or NIV (<jats:italic>n<\/jats:italic> =\u200945). Patients in the NIV group had more severe blood gas derangement. In both groups, mean arterial pCO<jats:sub>2<\/jats:sub> improved significantly (\u221210 (95% confidence interval: \u221214 to \u22126) mmHg) from baseline with no evidence of a differential effect between groups. Six (25%) patients, of whom three had comorbid obesity and two had sleep\u2010disordered breathing, were transitioned from HFNC to NIV. No significant differences in hospital length of stay, 30\u2010day readmission rate or 90\u2010day mortality were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HFNC might be a reasonable initial treatment for patients with mild acute hypercapnic respiratory failure who do not have comorbid obesity or sleep\u2010disordered breathing. A prospective study might help identify clinical factors or phenotypes predictive of success with this treatment modality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15400","type":"journal-article","created":{"date-parts":[[2021,6,6]],"date-time":"2021-06-06T13:00:07Z","timestamp":1622984407000},"page":"259-264","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and efficacy of high\u2010flow nasal cannula therapy in acute hypercapnic respiratory failure: a retrospective audit"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9274-1460","authenticated-orcid":false,"given":"Amin","family":"Golmohamad","sequence":"first","affiliation":[{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine The Prince Charles Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hay","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Tay","sequence":"additional","affiliation":[{"name":"Department of Thoracic Medicine The Prince Charles Hospital  Brisbane Queensland Australia"},{"name":"QIMR Berghofer Medical Research Institute  Brisbane Queensland Australia"},{"name":"University of Queensland  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-208209"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02426-2016"},{"key":"e_1_2_6_4_1","first-page":"CD004104","article-title":"Non\u2010invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease","author":"Osadnik CR","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2015.03.002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05590-5"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1503326"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.160570"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0576-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201706-425OC"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S159666"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.84.6.2115"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01308.2012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.04.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2547-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aucc.2007.08.001"},{"key":"e_1_2_6_17_1","first-page":"2089","article-title":"Effects of a nasal high\u2010flow system (nHF) on tidal volume, breathing rate, minute volume and I\/E\u2010ratio in healthy volunteers and patients with COPD","volume":"38","author":"Braunlich J","year":"2011","journal-title":"Eur Respir J"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.02086"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0006ED"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2002129"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12772"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S206567"},{"key":"e_1_2_6_23_1","unstructured":"StataCorp.Stata statistical software: release 15. 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