{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:26:45Z","timestamp":1777332405853,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The incidence of end\u2010stage organ disease in people living with human immunodeficiency virus (HIV) (PLWH) is increasing, as people live longer due to potent, tolerable antiretroviral therapy (ART). Consequently, the number of PLWH who would benefit from solid organ transplant (SOT) is rising. The SOT experience in PLWH in Australia remains limited.<\/jats:p><jats:p>Aim<\/jats:p><jats:p>To retrospectively review the outcomes for SOT in PLWH at our service, in Victoria, Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of PLWH undergoing SOT over a 15\u2010year period was performed. Adult PLWH age &gt;18\u2009years were eligible and identified from the Victorian HIV Service database. Descriptive statistics were used to summarise baseline demographics and clinical data, and outcomes following SOT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine virologically suppressed PLWH underwent SOT from HIV\u2010negative donors (five kidneys, two livers and two bilateral sequential lung transplants). All patients were male, with a median age of 57.3\u2009years (interquartile range (IQR)\u00a0=\u00a054.3\u201360.1) and CD4 count of 485 (IQR\u00a0=\u00a0342\u2013835) at transplantation, and comorbidities were common at baseline. After a median follow up of 3.9\u2009years (IQR\u00a0=\u00a02.7\u20137.6), 8 (89%) patents were alive, 7 (78%) had functioning grafts, although 5 (56%) experienced organ rejection. Infections were common. Two patients required modification to their ART due to significant drug\u2212drug interactions prior to transplant, while 5 (56%) had modifications post\u2010SOT. No patients experienced HIV virologic failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PLWH with end\u2010stage organ disease experience good clinical and functional outcomes and should be considered for SOT where indicated. However, multidisciplinary planning and care is essential to optimise care in this patient group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15423","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T16:20:20Z","timestamp":1623946820000},"page":"1780-1790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["<scp>Human immunodeficiency virus<\/scp> and solid organ transplantation: a <scp>15\u2010year<\/scp> retrospective audit at a tertiary Australian transplant centre"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-1780","authenticated-orcid":false,"given":"David W. J.","family":"Griffin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakhee","family":"Kotecha","sequence":"additional","affiliation":[{"name":"Lung Transplant Service Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gopal","family":"Basu","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine Alfred Hospital  Melbourne Victoria Australia"},{"name":"Central Clinical School Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Gow","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Austin Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jillian S. Y.","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine O.","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer F.","family":"Hoy","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Alfred Hospital and Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000001014"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60604-8"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hiv.12270"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1240"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223224"},{"issue":"3","key":"e_1_2_6_7_1","article-title":"Waitlist outcomes and access to liver transplantation for HIV+ candidates","volume":"17","author":"Shaffer A","year":"2017","journal-title":"Am J Transplant"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199805150-00008"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000001761"},{"key":"e_1_2_6_10_1","first-page":"435","article-title":"Survival in HIV\u2010positive transplant recipients compared with transplant candidates and with HIV\u2010negative controls","volume":"30","author":"Roland ME","year":"2016","journal-title":"AIDS"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.09.011"},{"key":"e_1_2_6_12_1","unstructured":"The Transplantation Society of Australia and New Zealand (TSANZ). Clinical Guidelines for Organ Transplantation from Deceased Donors Version 1.6 \u2013 May 2021. [updated 2021 May 4; cited 2021 Jun] 2021. Available from URL:https:\/\/tsanz.com.au\/storage\/documents\/TSANZ_Clinical_Guidelines_Version-16_11052021.pdf"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-020-05333-8"},{"key":"e_1_2_6_14_1","first-page":"1","article-title":"The first simultaneous pancreas, renal transplant in a patient with HIV in Australia","volume":"4","author":"Hasan T","year":"2018","journal-title":"J HIV Retro Virus"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13499"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12754"},{"key":"e_1_2_6_17_1","unstructured":"ANZDATA Registry.43rd Report Chapter 7: Kidney transplantation. Adelaide Australia: Australia and New Zealand Dialysis and Transplant Registry;2020."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12737"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2019.08.001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001674"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.23411"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.74"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04028.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14996"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000003107"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1001197"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000436905.54640.8c"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13840"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000000879"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2007.07.027"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb02487.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2019.05.001"},{"key":"e_1_2_6_33_1","unstructured":"US Department of Health Human ServicesGuidelines for the use of antiretroviral agents in adults and adolescents living with HIV. [cited 2021 Jun 3]. Available from URL:https:\/\/clinicalinfo.hiv.gov\/en\/guidelines"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2007.tb00839.x"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.02.011"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10414.1"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14419"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.02007.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2009.01.268"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.5500\/wjt.v6.i3.460"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.08.002"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/lt.22431"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13782"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000001712"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16569"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.15423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:37:46Z","timestamp":1692671866000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.15423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,11]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/imj.15423"],"URL":"https:\/\/doi.org\/10.1111\/imj.15423","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,11]]},"assertion":[{"value":"2021-02-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}