{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:47:53Z","timestamp":1790624873018,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fibromyalgia presents with symptoms of widespread pain, fatigue, sleeping and cognitive disturbances as well as other somatic symptoms. It often overlaps with other conditions termed \u2018central sensitivity syndromes\u2019, such as irritable bowel syndrome, chronic fatigue syndrome and temporomandibular disorder. Central sensitisation, mediated by amplified processing in the central nervous system, has been identified as the key pathogenic mechanism in these disorders. The term \u2018central sensitivity\u2019 can be used to describe collectively the clinical presentation of these disorders. Fibromyalgia is highly prevalent in most rheumatic diseases as well as non\u2010rheumatic chronic diseases and if unrecognised results in high morbidity. It is diagnosed clinically after excluding important differential diagnoses. Diagnostic criteria have been developed as tools to help identify and diagnose fibromyalgia. Such tools can fulfil an important need when managing patients with rheumatic disease and other chronic diseases as a way to identify fibromyalgia and improve patient outcomes. Treatment involves an integrated approach including education, exercise, stress reduction and pharmacological therapies targeting the central nervous system. This approach is suitable for all presentations of central sensitivity and some central sensitivity syndromes have additional treatment options specific to the clinical presentation.<\/jats:p>","DOI":"10.1111\/imj.15430","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T16:20:23Z","timestamp":1623946823000},"page":"1990-1998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Central sensitivity and fibromyalgia"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-7774","authenticated-orcid":false,"given":"Veronica","family":"Mezhov","sequence":"first","affiliation":[{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Rheumatology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6712-1331","authenticated-orcid":false,"given":"Emma","family":"Guymer","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Rheumatology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7896-055X","authenticated-orcid":false,"given":"Geoffrey","family":"Littlejohn","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Rheumatology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2006.12.009"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.030"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2007.09.003"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/papr.12302"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1252"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3266"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-020-00506-w"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20140"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2016.06.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001299"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key075.533"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.190149"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00392-5"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.08.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000507"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42843"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.06.006"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2015.01.003"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2011.01168.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05344.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397112666151231113438"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2012.268"},{"key":"e_1_2_7_24_1","first-page":"79","article-title":"Central processes underlying fibromyalgia","volume":"3","author":"Littlejohn G","year":"2018","journal-title":"EMJ"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573397111666150619095125"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jabr.12137"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.02.002"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/157339711102150702112236"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez028"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/585419"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3208-7"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201488"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3306"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez303"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-017-3792-4"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.09.027"},{"key":"e_1_2_7_37_1","unstructured":"International Classification of Diseases (ICD \u2010 11).2020."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002018"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.090579"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2018.20.1\/whauser"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330203"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737159.2020.1858054"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.100594"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2016.08.012"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.24553"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1053\/berh.1999.0032"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.39213"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.10.008"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24202"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182a8eb1f"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2015.01.036"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.110026"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.15430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T07:01:34Z","timestamp":1693206094000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.15430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/imj.15430"],"URL":"https:\/\/doi.org\/10.1111\/imj.15430","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"2020-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}