{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:52:40Z","timestamp":1787014360597,"version":"build-2736575974"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Increased recipient and donor age are associated with worse solid organ pancreas transplant outcomes. However, donor and recipient age criteria vary between jurisdictions. We systematically reviewed studies reporting the association between transplanting older recipients and donors beyond current Transplantation Society of Australia and New Zealand (TSANZ) limits with solid pancreas transplant outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To review current outcomes of solid pancreas transplantation in recipients and donors over the TSANZ reference ages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Studies comparing transplant outcomes between a reference\u2010age and an older\u2010age donor (&gt;45\u2009years) or recipient (\u226550\u2009years) cohort for solid pancreas transplantation were included. Primary outcomes were pancreas\/kidney graft and patient survival at 1 and 5\u2009years. Secondary outcomes were post\u2010transplant complications (graft thrombosis, acute rejection and relaparotomy rates).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eleven studies were included (two studies assessing solid pancreas outcomes between older vs reference\u2010aged donors and nine studies assessing outcomes between older vs reference\u2010aged recipients). Seven of 11 studies were judged to be at high risk of bias. Primary and secondary outcomes were not significantly different between recipient age groups in nine studies. A sensitivity analysis of older versus reference\u2010aged studies excluding studies at high risk of bias also showed non\u2010inferior primary and secondary outcomes at 1\u00a0year. Two studies comparing outcomes by donor age showed worse graft survival but non\u2010inferior patient survival with older donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Increased donor or recipient age alone should not absolutely contraindicate solid pancreas transplantation, especially if other risk predictors are minimised.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/imj.15464","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T08:06:39Z","timestamp":1627891599000},"page":"1569-1586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Solid pancreas transplant outcomes with increased donor and recipient ages compared with reference ages: a systematic review"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5268-5345","authenticated-orcid":false,"given":"Jonathan E. H.","family":"Ling","sequence":"first","affiliation":[{"name":"Department of Nephrology Monash Health  Melbourne Victoria Australia"},{"name":"Centre for Inflammatory Diseases, Department of Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi Zhou","family":"Choo","sequence":"additional","affiliation":[{"name":"Barwon Health Renal Services  Geelong Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevan R.","family":"Polkinghorne","sequence":"additional","affiliation":[{"name":"Department of Nephrology Monash Health  Melbourne Victoria Australia"},{"name":"Centre for Inflammatory Diseases, Department of Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Epidemiology and Preventive Medicine School of Public Health and Preventive Medicine, Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kanellis","sequence":"additional","affiliation":[{"name":"Department of Nephrology Monash Health  Melbourne Victoria Australia"},{"name":"Centre for Inflammatory Diseases, Department of Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2007.01818.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.12407"},{"key":"e_1_2_8_4_1","unstructured":"TSANZClinical guidelines for organ transplantation from deceased donors version 1.4. The Transplantation Society of Australia and New Zealand; 2020."},{"key":"e_1_2_8_5_1","unstructured":"OPTNPolicy 11: Allocation of pancreas kidney\u2010pancreas and islets. Organ Procurement and Transplantation Network; 2020; 250\u2013258. USA."},{"key":"e_1_2_8_6_1","unstructured":"NHSBTPOL199\/11 \u2010 Pancreas transplantation: organ allocation. NHS Blood and Transplant; 2020. United Kingdom"},{"key":"e_1_2_8_7_1","unstructured":"deBoerJ.Chapter 7 ET Pancreas Allocation System (EPAS) version 5.4. 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