{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:14:09Z","timestamp":1783350849803,"version":"3.54.6"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical parathyroidectomy may be required for severe and refractory secondary hyperparathyroidism (SHPT) in patients with chronic kidney disease (CKD). Parathyroidectomy is associated with long\u2010term survival benefit despite an increase in short\u2010term morbidity and mortality. Global variation in practice exists, with limited Australian data on outcomes following parathyroidectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate clinical outcomes of patients with chronic kidney disease undergoing surgical parathyroidectomy for secondary hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of patients who underwent parathyroidectomy for SHPT between January 2010 and December 2019 at a single tertiary referral centre in Melbourne, Australia. Biochemical markers and medications were assessed 12 months pre\u2010 and post\u2010surgery. Clinical outcomes, including hospital readmission, cardiovascular events and mortality were assessed following surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 10\u2010year study period, 129 patients underwent parathyroidectomy for SHPT (mean age 50.7 \u00b1\u200915\u2009years; 109 (85%) on dialysis). Significant immediate post\u2010operative complications were seen in eight (6%) patients, requiring admission to the intensive care unit (<jats:italic>n<\/jats:italic> =\u20096) or return to theatre (<jats:italic>n<\/jats:italic> =\u20092). Within the first 6 months, 24 (19%) patients required hospital readmission. Within 12 months post\u2010parathyroidectomy, 100 (78%) and 103 (80%) patients experienced at least one episode of hypercalcaemia (corrected calcium &gt;2.6\u2009mmol\/L) or hypocalcaemia (corrected calcium &lt;2.1\u2009mmol\/L) respectively. Over a 12\u2010month period, there were six (5%) deaths and eight (6%) patients experienced a major cardiovascular event.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant fluctuations in serum calcium levels are common post\u2010parathyroidectomy; however, long\u2010term morbidity and mortality in our cohort were lower than previously reported, highlighting that parathyroidectomy in a carefully selected cohort is safe for severe SHPT refractory to medical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15467","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T13:07:09Z","timestamp":1627909629000},"page":"2107-2115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Outcomes following parathyroidectomy for secondary hyperparathyroidism in patients with chronic kidney disease: a single\u2010centre study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8424-5782","authenticated-orcid":false,"given":"Parul","family":"Bali","sequence":"first","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2853-5096","authenticated-orcid":false,"given":"Nigel D.","family":"Toussaint","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Tiong","sequence":"additional","affiliation":[{"name":"Department of Nephrology The Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Medicine (RMH) The University of Melbourne  Melbourne 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