{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:05:31Z","timestamp":1767665131794,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metabolic\u2010associated fatty liver disease (MAFLD) is a leading cause of chronic liver disease with increasingly recognised associations with gestational diabetes (GDM), including within the antenatal period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the relationship between MAFLD in pregnancy and development of GDM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty pregnant women were enrolled before 24\u2009weeks gestation from a multiethnic obstetrics service in Sydney, Australia. Two FibroScan\u00ae assessments were performed, one prior to 24\u2009weeks and one after 30\u2009weeks gestation, to assess hepatic steatosis and stiffness. A control attenuated parameter (CAP) score \u2265\u2009233.5 dB\/m signified MAFLD. GDM was determined by an antenatal 75\u2010g oral glucose tolerance testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six (12%) women had evidence of FibroScan\u00ae\u2010detected MAFLD in early pregnancy, while none had abnormal hepatic stiffness. Sixteen (32%) women developed GDM. No significant difference was observed in GDM rates (50% vs 29.5%; <jats:italic>P<\/jats:italic> =\u20090.37) between those with MAFLD in early pregnancy and those without. At the second scan (completed by 34 women), those who developed GDM had a lower observed mean increase in CAP scores (11.1 \u00b1\u200923.3 dB\/m vs \u221214.9 \u00b1\u200926.0 dB\/m; <jats:italic>P<\/jats:italic> =\u20090.004) and lower maternal weight gain (0.6 \u00b1\u20090.2 kg\/week vs 0.4 \u00b1\u20090.2 kg\/week; <jats:italic>P<\/jats:italic> =\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no statistically significant association between FibroScan\u00ae\u2010detected MAFLD in early pregnancy and subsequent development of GDM in this pilot study. Maternal weight gain may be associated with changes in the CAP scores, which reflect steatosis, during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15499","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T15:28:41Z","timestamp":1629905321000},"page":"2157-2164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antenatal <scp>FibroScan<\/scp>\u00ae assessment for metabolic\u2010associated fatty liver in pregnant women at risk of gestational diabetes from a multiethnic population: a pilot study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0694-5358","authenticated-orcid":false,"given":"Difei","family":"Deng","sequence":"first","affiliation":[{"name":"School of Medicine University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Diabetes and Endocrinology Nepean Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"George","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sydney  Sydney New South Wales Australia"},{"name":"Storr Liver Centre, Westmead Institute for Medical Research Westmead Hospital and University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmintra","family":"Pasupathy","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sydney  Sydney New South Wales Australia"},{"name":"Institute of Reproduction, Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngai Wah","family":"Cheung","sequence":"additional","affiliation":[{"name":"School of Medicine University of Sydney  Sydney New South Wales Australia"},{"name":"Department of Diabetes and Endocrinology Westmead Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190117102111"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.312"},{"key":"e_1_2_6_4_1","first-page":"9072","article-title":"Non\u2010alcoholic fatty liver disease and type 2 diabetes mellitus: the liver disease of our age?","volume":"20","author":"Firneisz G","year":"2014","journal-title":"World J Gastroenterol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.72"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0098-8"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.10.1862"},{"key":"e_1_2_6_8_1","first-page":"221","article-title":"Implications of nonalcoholic fatty liver disease on pregnancy and maternal and child outcomes","volume":"15","author":"Hershman M","year":"2019","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.57"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-2956-3"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1017"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2018-000549"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2019.06.006"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2016.43"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/09674845.2018.1492205"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4779-8"},{"key":"e_1_2_6_17_1","unstructured":"McIntyreH RossG VriesD.ADIPS Consensus Guidelines for the Testing and Diagnosis of Gestational Diabetes Mellitus in Australia.2013."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2019-001186"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0215326"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.292.6512.13"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02820.x"},{"key":"e_1_2_6_22_1","unstructured":"NankervisA McIntyreHD MosesR RossG CallawayL PorterCet al. 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