{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:19:56Z","timestamp":1791879596715,"version":"4.3.4"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T00:00:00Z","timestamp":1658534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Internationally, clinical and economic advantages of low\u2010risk penicillin delabelling have been explored, supporting changes to healthcare delivery systems where penicillin delabelling is embedded into inpatient usual care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine if economic advantages of low\u2010risk inpatient penicillin delabelling, described in the international literature, are realised in the Australian context.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This explorative economic evaluation had prospective patient data collection between January and August 2019, across two Australian health services. Part 1: determine the cost per effectively delabelled patient for Penicillin Allergy Delabeling Program inpatients (PADP cohort) compared with Outpatient Antibiotic Allergy Testing Service outpatients (OAATS cohort). Part 2: a cost analysis to compare hospital costs for inpatients with low\u2010risk penicillin allergy who did (PADP cohort) and did not (usual care cohort) undergo PADP delabelling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Part 1: the PADP (<jats:italic>n<\/jats:italic> =\u2009350) and OAATS (<jats:italic>n<\/jats:italic> =\u200927 patients, <jats:italic>n<\/jats:italic> =\u200936 individual visits) cohorts were comparable. In PADP, costs\/proportion delabelled was $20.10\/0.98, equating to $20.51 per effectively delabelled patient; in OAATS, it was $181.24\/0.50, equating to $362. Compared with OAATS, PADP was associated with savings of $341.97 per effectively delabelled patient, indicating the outpatient testing was the dominated strategy, being more costly and less effective. Part 2: the PADP (<jats:italic>n<\/jats:italic> =\u2009218) and usual care (<jats:italic>n<\/jats:italic> =\u200932) cohorts were comparable. Significantly favouring the delabelled PADP cohort, the mean difference per patient was \u22124.41\u2009days (95% confidence interval: \u22127.64, \u22121.18) and \u2212$9467.72 (95% confidence interval: \u2212$15\u2009419.98, \u2212$3515.46).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consistent with international literature, delabelling low\u2010risk penicillin allergies in the inpatient setting had economic advantages in the Australian context. Fully powered economic evaluations are urgently required to consolidate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15532","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T07:57:51Z","timestamp":1631692671000},"page":"74-83","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Penicillin Allergy Delabeling Program: an exploratory economic evaluation in the Australian context"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8825-5109","authenticated-orcid":false,"given":"Natasha K.","family":"Brusco","sequence":"first","affiliation":[{"name":"Health Economics Alpha Crucis Group  Melbourne Victoria Australia"},{"name":"Rehabilitation, Ageing and Independent Living (RAIL) Research Centre Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bury","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Austin Health  Melbourne Victoria Australia"},{"name":"Department of Pharmacy Austin Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyra Y. 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