{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:19:00Z","timestamp":1767835140234,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Viral community\u2010acquired pneumonia (CAP) is a potentially serious illness, particularly in adult patients with underlying chronic conditions. In addition to the most recent SARS\u2010CoV\u20102, influenza, and respiratory syncytial virus (RSV) are considered the most relevant causes of viral CAP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe the clinical features of hospitalised adults admitted for influenza\u2010A\/B and RSV pneumonia and analyse, according to aetiology, factors associated with non\u2010invasive ventilation (NIV) failure and in\u2010hospital death (IHD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective and multi\u2010centre study of all adults who were admitted for laboratory\u2010confirmed influenza\u2010A\/B or RSV pneumonia, during two consecutive winter seasons (October\u2013April 2017\u20132018 and 2018\u20132019) in three tertiary hospitals in Portugal, Italy and Cyprus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 356 adults were included in the study. Influenza\u2010A, influenza\u2010B and RSV were deemed to cause pneumonia in 197 (55.3%), 85 (23.9%) and 74 (20.8%) patients, respectively. Patients with both obstructive sleep apnoea or obesity hypoventilation syndrome and influenza\u2010A virus pneumonia showed a higher risk for NIV failure (odds ratio (OR) 4.66; 95% confidence interval (CI) 1.42\u201315.30). Patients submitted to NIV showed a higher risk for IHD, regardless of comorbidities (influenza\u2010A OR 3.00; 95% CI 1.35\u20136.65, influenza\u2010B OR 4.52; 95% CI 1.13\u201318.01, RSV OR 5.61; 95% CI 1.26\u201324.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The increased knowledge of influenza\u2010A\/B and RSV pneumonia burden may contribute to a better management of patients with viral CAP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15583","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T13:48:04Z","timestamp":1633960084000},"page":"404-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Burden of primary influenza and respiratory syncytial virus pneumonia in hospitalised adults: insights from a 2\u2010year multi\u2010centre cohort study (2017\u20132018)"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6726-2716","authenticated-orcid":false,"given":"Matteo","family":"Boattini","sequence":"first","affiliation":[{"name":"Microbiology and Virology Unit University Hospital Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Charrier","sequence":"additional","affiliation":[{"name":"Department of Public Health and Paediatrics University of Torino  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 4 Hospital de Santa Marta, Central Lisbon Hospital Centre  Lisbon Portugal"},{"name":"NOVA Medical School Universidade Nova de Lisboa  Lisbon 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