{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:11:36Z","timestamp":1787602296984,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early and accurate non\u2010invasive diagnosis of liver fibrosis is important for reducing the burden of cirrhosis and related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This cross\u2010sectional study compares shear wave elastography (SWE), transient elastography (TE) and clinical markers of chronic liver disease in patients with various liver disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Liver ultrasound with SWE was performed on 421 adult patients, 227 of whom also had TE. Patient age, gender, body mass index (BMI), liver disease aetiology and laboratory results were recorded. Associations between SWE, TE and other tests for liver fibrosis and chronic liver disease severity were sought. Advanced liver fibrosis was defined as liver stiffness measurement (LSM) equivalent to \u2265F3 using Metavir staging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were predominantly male (68%), with mean (standard deviation) age 54 (13) years, BMI 28 (6) kg\/m<jats:sup>2<\/jats:sup> and serum alanine aminotransferase (ALT) 39 (27) U\/L. Liver disorders were predominantly non\u2010alcoholic fatty liver disease (NAFLD), chronic hepatitis B (CHB), chronic hepatitis C (CHC) and alcohol\u2010related liver disease. The median (interquartile range) LSM was 10 (6\u201320) kPa with SWE and 9.2 (6\u201321) kPa with TE. Advanced liver fibrosis was associated with older age, higher BMI, model for end\u2010stage liver disease score, aspartate aminotransferase (AST), AST\/ALT ratio, AST to platelet ratio index, fibrosis\u20104 index and Hepascore. SWE and TE LSM were positively correlated, particularly for NAFLD and CHC. SWE LSM predicted ultrasound and endoscopy\u2010diagnosed portal hypertension and oesophageal varices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Across various liver diseases, SWE is at least comparable with TE and other non\u2010invasive tests of liver fibrosis. 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