{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:33:51Z","timestamp":1783953231424,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>People with serious mental illness (SMI) are underserved from a hepatitis C virus (HCV) screening and treatment perspective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the HCV care cascade in people with SMI and to pilot a supported HCV treatment integration programme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HCV prevalence was retrospectively analysed from 4492 consecutive individuals admitted to a tertiary hospital mental health service between January 2017 and December 2018. Subcohort analysis of screening patterns and predictors of seropositive infection was performed. Referral pathways and community care integration were analysed for HCV\u2010positive individuals, and a prospective community\u2010based \u2018identify and treat\u2019 HCV programme was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Screening for HCV had been performed in 18.6% (835\/4492) of the cohort. Seroprevalence was 4.6% (207\/4492). HCV seropositivity was associated with age &gt;40 years (odds ratio (OR) =\u20099.30; confidence interval (CI) 3.69\u201323.45; <jats:italic>P<\/jats:italic> &lt;\u20090.01), injecting drug use (OR\u00a0=\u00a024.26; CI 8.99\u201365.43; <jats:italic>P<\/jats:italic> &lt;\u20090.01) and previous incarceration (OR\u00a0=\u00a012.26; CI 4.51\u201333.31; <jats:italic>P<\/jats:italic> &lt;\u20090.01). In a cohort of treatment\u2010eligible individuals, 43.3% (90\/208) had neither been referred to specialist services or general practitioners for HCV management. Amongst those referred to specialist services, 64.7% (57\/88) did not attend scheduled follow up, and 48.3% (15\/31) of attendees were lost to follow up. Through an intensified community access programme, 10 people were successfully treated for HCV, although 22 could not be engaged.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>People with SMI are underserved by traditional models of HCV healthcare. Intensified community\u2010based support can partially bolster the treatment cascade, although investment in innovative screening and management strategies are required to achieve healthcare parity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15604","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T04:56:41Z","timestamp":1635742601000},"page":"700-708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hepatitis C virus in people with serious mental illness: an analysis of the care cascade at a tertiary health service with a pilot \u2018identify and treat\u2019 strategy"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-0032","authenticated-orcid":false,"given":"Michael","family":"Braude","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Monash Health  Melbourne Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4983-6103","authenticated-orcid":false,"given":"Danny","family":"Con","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2928-1291","authenticated-orcid":false,"given":"Ian","family":"Woolley","sequence":"additional","affiliation":[{"name":"School of Clinical Sciences Monash University  Melbourne Victoria Australia"},{"name":"Department of Infectious Diseases Monash Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Sundram","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Monash Health  Melbourne Victoria Australia"},{"name":"Psychological Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Mental Health, Monash Health  Melbourne Victoria Australia"},{"name":"Psychological Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk","family":"Dev","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Monash Health  Melbourne Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Sievert","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Monash Health  Melbourne Victoria Australia"},{"name":"School of Clinical Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,13]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"World Health Organization (WHO). 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