{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:48:49Z","timestamp":1765828129405,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is no registry data on morbidity and mortality of high\u2010risk cutaneous squamous cell carcinoma (cSCC) in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the clinicopathological features, mortality and morbidity in high\u2010risk cSCC patients in Western Australia (WA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted through hospital record review on cSCC patients discussed at multidisciplinary meetings at the two largest WA hospitals between March 2015 and December 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 141 patients, 129 were evaluable, with median follow up of 43.9 (range 3.0\u201353.2) months. Patients were predominantly older males (84%) with significant comorbidities (Charlson Comorbidity Index (CCI) \u22655; 76%) and history of previous nonmelanoma skin cancer (57%) with advanced disease (57% stage IV without distant metastasis; American Joint Committee on Cancer, 7th edition). Pathological high\u2010risk features were common including nodal extracapsular extension (47%) and cranial nerve involvement (16%). Clinical morbidity was significant with a median of 2 (range 0\u201313) excisions and 2 (range 0\u201321) cSCC\u2010related hospitalisations for any cSCC event following the index case discussion. Recurrences of the primary index lesion occurred in 60% of patients and 20% had \u22652 recurrences. Median overall survival for patients with nonmetastatic disease was 39.8 (range 25.9\u201353.7) months and 16.1 (range 0.2\u201332.0) months for metastatic disease. CCI \u22655, advanced nodal stage and \u22652 recurrences were significantly associated with mortality on multivariable analyses (<jats:italic>P<\/jats:italic> &lt;\u20090.05). Nodal extracapsular extension and any recurrences were identified as significant risk factors for disease\u2010specific mortality on multivariable analyses (<jats:italic>P<\/jats:italic> &lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010risk cSCC patients have significant health needs represented by high\u2010baseline comorbidities, multiplicity of cSCC events and the number of healthcare\u2010associated interventions. There is an unmet need for robust cancer data collection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15630","type":"journal-article","created":{"date-parts":[[2021,11,20]],"date-time":"2021-11-20T13:34:05Z","timestamp":1637415245000},"page":"944-951","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinicopathological characteristics and clinical morbidity in high\u2010risk head and neck cutaneous squamous cell carcinoma patients in Western Australia"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5717-6507","authenticated-orcid":false,"given":"Piyush","family":"Grover","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Sir Charles Gairdner Hospital  Perth Western Australia Australia"},{"name":"Department of Medical Oncology Fiona Stanley Hospital  Perth Western Australia 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