{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:00:34Z","timestamp":1777521634274,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bronchiectasis has been observed in association with systemic sclerosis (SSc). Theorised aetiology includes aspiration related to oesophageal dysmotility, immunosuppressant medication use and the direct effect of collagen deposition on airway calibre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To detail bronchiectasis prevalence in an SSc population who have had a high\u2010resolution computed tomography (HRCT) of the thorax. We assessed whether oesophageal dysmotility, demographic variables, SSc duration or subclass were associated with bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants in the Australian Scleroderma Cohort Study (ASCS) with a HRCT were included. The ASCS provided demographic and clinical data. HRCT studies were reviewed for bronchiectasis, oesophageal dilatation and interstitial lung disease (ILD). Traction bronchiectasis associated with ILD was recorded as a separate entity to bronchiectasis. Oesophageal dysmotility was defined by symptoms and\/or oesophageal dilatation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 256 participants, 16.4% (<jats:italic>n<\/jats:italic> =\u200942) had bronchiectasis. Logistic regression analysis revealed no significant association between bronchiectasis and oesophageal dysmotility (observed in 95.7%), any demographic variable, SSc duration or subclass. A negative association between bronchiectasis and ILD was observed (<jats:italic>P<\/jats:italic> =\u20090.009; odds ratio 0.322; 95% confidence intervals 0.137\u20130.756).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Those with SSc appear to have an increased risk for bronchiectasis. Since bronchiectasis was not more frequent in participants with a longer duration of SSc, we hypothesise that its development is not related to immunosuppression alone. Oesophageal dysmotility was almost universal in our population such that its effect on bronchiectasis development could not be concluded. A negative association between bronchiectasis and ILD reflects that bronchiectasis occurring alongside ILD was recorded as a separate entity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15661","type":"journal-article","created":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T10:11:45Z","timestamp":1639217505000},"page":"1204-1211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The emerging association between bronchiectasis and systemic sclerosis: assessing prevalence and potential causality"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-2077","authenticated-orcid":false,"given":"Rosemary","family":"Smith","sequence":"first","affiliation":[{"name":"Department of General Medicine Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Harrison","sequence":"additional","affiliation":[{"name":"Institute for Health Research University of Notre Dame  Fremantle Western Australia Australia"},{"name":"Department of Respiratory Medicine Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay\u2010Vin","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Radiology Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan","family":"Adler","sequence":"additional","affiliation":[{"name":"Envision Medical Imaging  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Bulsara","sequence":"additional","affiliation":[{"name":"Institute for Health Research University of Notre Dame  Fremantle Western Australia Australia"},{"name":"School of Population and Global Health University of Western Australia  Perth Western Australia Australia"},{"name":"Division of Surgery and Interventional Science University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Sahhar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Monash Health  Melbourne Victoria Australia"},{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Rheumatology St Vincent\u2019s Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanna","family":"Proudman","sequence":"additional","affiliation":[{"name":"Rheumatology Unit Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"School of Medicine University of Adelaide  Adelaide South Australia Australia"},{"name":"Arthritis Australia  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandana","family":"Nikpour","sequence":"additional","affiliation":[{"name":"Department of Medicine Monash University  Melbourne Victoria Australia"},{"name":"Department of Medicine and Rheumatology University of Melbourne at St Vincent\u2019s Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Gabbay","sequence":"additional","affiliation":[{"name":"School of Medicine University of Notre Dame  Fremantle Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2009.tb02839.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1999.tb01587.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.1995.tb02854.x"},{"key":"e_1_2_7_5_1","first-page":"31","article-title":"Scleroderma: the Tassie experience","volume":"39","author":"Zochling J","year":"2009","journal-title":"Intern Med J"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13203"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.066068"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2008.01823.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21131"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30480-1"},{"key":"e_1_2_7_11_1","first-page":"187","article-title":"Bronchiectasis in systemic sclerosis. 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