{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:17:59Z","timestamp":1747185479479,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T00:00:00Z","timestamp":1643846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It is well documented that patients with chronic metabolic diseases, such as diabetes and obesity, are adversely affected by the COVID\u201019 pandemic. However, when the subject is rare metabolic diseases, there are not enough data in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the course of COVID\u201019 among patients with Gaucher disease (GD), the most common lysosomal storage disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Based on the National Health System data, a retrospective cohort of patients with confirmed (polymerase chain reactionpositive) COVID\u201019 infection (<jats:italic>n<\/jats:italic> =\u2009149\u2009618) was investigated. The adverse outcomes between patients with GD (<jats:italic>n<\/jats:italic> =\u200939) and those without GD (<jats:italic>n<\/jats:italic> =\u2009149\u2009579) were compared with crude and propensity score\u2010matched (PSM) groups. The outcomes were hospitalisation, the composite of intensive care unit (ICU) admission and\/or mechanical ventilation and mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with GD were significantly older and had a higher frequency of hypertension (HT), Type 2 diabetes mellitus (T2DM), dyslipidaemia, asthma or chronic obstructive pulmonary disease, chronic kidney disease, coronary artery disease, heart failure and cancer. Although hospitalisation rates in Gaucher patients were found to be higher in crude analyses, the PSM models (model 1, age and gender matched; model 2, matched for age, gender, HT, T2DM and cancer) revealed no difference for the outcomes between patients with GD and the general population. According to multivariate regression analyses, having a diagnosis of GD was not a significant predictor for hospitalisation (<jats:italic>P<\/jats:italic> =\u20090.241), ICU admission\/mechanical ventilation (<jats:italic>P<\/jats:italic> =\u20090.403) or mortality (<jats:italic>P<\/jats:italic> =\u20090.231).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>According to our national data, SARS\u2010CoV\u20102 infection in patients with GD does not have a more severe course than the normal population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15673","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T11:28:36Z","timestamp":1640258916000},"page":"379-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["No association of Gaucher disease with COVID\u201019\u2010related outcomes: a nationwide cohort 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Metabolism, Department of Internal Medicine Faculty of Medicine, Kecioren Training and Research Hospital, University of Health Sciences  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naim","family":"Ata","sequence":"additional","affiliation":[{"name":"Department of Strategy Development Ministry of Health  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Sahin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine Faculty of Medicine, Ankara University  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serpil","family":"Salman","sequence":"additional","affiliation":[{"name":"Endocrinology and Metabolism Medica Clinic  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Sahin","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, 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