{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T21:05:56Z","timestamp":1789074356033,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,20]],"date-time":"2022-02-20T00:00:00Z","timestamp":1645315200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Empiric antibiotic therapy in suspected prosthetic joint infection should cover likely pathogens while avoiding overly broad\u2010spectrum antibiotics. We analysed individual patient data from a large prospective cohort study (Prosthetic Joint Infection in Australia and New Zealand, Observational (PIANO)) and found that causative organisms vary with the presentation type, with early post\u2010operative infections more likely to be polymicrobial (41%) compared with late acute infections (10%). We thus propose empirical regimens tailored to the presentation type and presence or absence of sepsis.<\/jats:p>","DOI":"10.1111\/imj.15677","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T01:07:02Z","timestamp":1645405622000},"page":"322-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Proposed empiric antibiotic therapy for prosthetic joint infections: an analysis of the Prosthetic Joint Infection in Australia and New Zealand, Observational (<scp>PIANO)<\/scp> cohort"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9864-5699","authenticated-orcid":false,"given":"Joshua S.","family":"Davis","sequence":"first","affiliation":[{"name":"Global and Tropical Health Division Menzies School of Health Research and Charles Darwin University  Darwin Northern Territory Australia"},{"name":"Department of Infectious Diseases John Hunter Hospital  Newcastle New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Metcalf","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Christchurch Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Paterson","sequence":"additional","affiliation":[{"name":"UQ Centre for Clinical Research University of Queensland  Brisbane Queensland Australia"},{"name":"Herston Infectious Diseases Institute (HeIDI) Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James O.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Royal Perth Hospital  Perth Western Australia Australia"},{"name":"PathWest Laboratory medicine Fiona Stanley Hospital  Perth Western Australia Australia"},{"name":"Department of Infectious Diseases Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fiona Stanley Hospital  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-5351","authenticated-orcid":false,"given":"Laurens","family":"Manning","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fiona Stanley Hospital  Perth Western Australia Australia"},{"name":"Medical School University of Western Australia  Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2009.04.027"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11999-009-1013-5"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2018.09.032"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis966"},{"key":"e_1_2_4_6_1","first-page":"ofaa068","article-title":"Clinical characteristics, etiology, and initial management strategy of newly diagnosed periprosthetic joint infection: a multicenter, prospective observational cohort study of 783 patients. 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