{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T02:34:03Z","timestamp":1775010843294,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The Northern Territory (NT) of Australia is currently experiencing a syphilis epidemic. Neurosyphilis is commonly considered in the differential diagnosis for patients presenting with neurologic conditions such as dementia and stroke in the NT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore the local epidemiologic, diagnostic and treatment complexities of neurosyphilis in the NT and produce a guideline for clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A database search was undertaken and local and global neurosyphilis guidelines were analysed. A guideline was created based on findings of the critical review and consultation with local multidisciplinary experts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neurosyphilis is frequently encountered in the NT but studies suggest it is often undertreated. Dementia is the most common clinical presentation locally. Establishing a diagnosis of neurosyphilis is complex and requires stepwise evaluation of clinical, laboratory and radiological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A clinical guideline and algorithm have been developed for the diagnosis and management of patients with neurosyphilis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15691","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T14:43:07Z","timestamp":1641739387000},"page":"738-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neurosyphilis in the Northern Territory of Australia: a clinical guideline"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5142-313X","authenticated-orcid":false,"given":"Johanna Marie","family":"Birrell","sequence":"first","affiliation":[{"name":"Public Health Unit Northern Territory Centre for Disease Control  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Medicine Royal Darwin Hospital  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoji","family":"Gunathilake","sequence":"additional","affiliation":[{"name":"Public Health Unit Northern Territory Centre for Disease Control  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicki Lynn","family":"Krause","sequence":"additional","affiliation":[{"name":"Public Health Unit Northern Territory Centre for Disease Control  Darwin Northern Territory Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(36)90081-0"},{"key":"e_1_2_7_3_1","first-page":"285","article-title":"Treponemal infection in the Australian Northern Territory aborigines","volume":"46","author":"Garner MF","year":"1972","journal-title":"Bull World Health Organ"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.2011.tb03089.x"},{"key":"e_1_2_7_5_1","unstructured":"Department of HealthMultijurisdictional Syphilis Outbreak Surveillance Report: December 2019[Cited July 2021]. 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