{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:15:57Z","timestamp":1790914557280,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The global burden of chronic kidney disease (CKD) has increased significantly over the past few decades. This reflects the rising prevalence of type 2 diabetes mellitus (T2DM) and hypertension, two leading causes of CKD. Hypertension, which can also be a complication of CKD, accelerates renal disease progression and augments cardiovascular risk, especially in individuals with diabetic kidney disease. Hence, blood pressure (BP) reduction is a vital component of CKD management. Sodium\u2010glucose co\u2010transporter 2 (SGLT2) inhibitors are a relatively novel class of medications developed to treat T2DM by inducing glycosuria and hence, lowering glycaemia. Additionally, SGLT2 inhibitors are antihypertensive, renoprotective and cardioprotective, even in individuals without T2DM, making them effective therapeutic agents for CKD. Another therapy that has proven to be antihypertensive, renoprotective and cardioprotective is dietary sodium restriction. This review evaluates the potential combined benefits of SGLT2 inhibition and dietary sodium restriction on the BP and renal parameters of individuals with CKD.<\/jats:p>","DOI":"10.1111\/imj.15727","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T07:32:05Z","timestamp":1646724725000},"page":"1666-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sodium\u2010glucose co\u2010transporter 2 inhibitor therapy: use in chronic kidney disease and adjunctive sodium restriction"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-052X","authenticated-orcid":false,"given":"Mansi","family":"Tiwary","sequence":"first","affiliation":[{"name":"St Vincent's Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"School of Pharmacy University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara Y.","family":"Milder","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"Department of Diabetes and Endocrinology St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"Healthy Ageing Garvan Institute of Medical Research  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-587X","authenticated-orcid":false,"given":"Sophie L.","family":"Stocker","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"School of Pharmacy University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6045-6937","authenticated-orcid":false,"given":"Richard O.","family":"Day","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Clinical Pharmacology and Toxicology St Vincent's Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-0973","authenticated-orcid":false,"given":"Jerry R.","family":"Greenfield","sequence":"additional","affiliation":[{"name":"St Vincent's Clinical School University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Diabetes and Endocrinology St Vincent's Hospital  Sydney New South Wales Australia"},{"name":"Healthy Ageing Garvan Institute of Medical Research  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"337","article-title":"KDIGO clinical practice guideline for the management of blood pressure in chronic kidney disease","volume":"2","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Blood Pressure Work Group","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"key":"e_1_2_11_4_1","unstructured":"Australian Institute of Health and Welfare (AIHW). 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