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However, the potential risk of upper gastrointestinal (UGI) ulceration and bleeding associated with low\u2010dose aspirin use is often not appreciated by prescribers and older consumers. Among 133 serial patients with UGI bleeding, aspirin\u2010users aged \u226570 years had a ninefold increased likelihood of overt UGI bleeding compared with non\u2010users, reducing by 90% in regular proton\u2010pump inhibitor users (adjusted odds ratio 0.10). We recommend risk\u2010versus\u2010benefit discussions when recommending aspirin to older people.<\/jats:p>","DOI":"10.1111\/imj.15732","type":"journal-article","created":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T22:07:40Z","timestamp":1649887660000},"page":"663-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prior oral proton\u2010pump inhibitor use is associated with reduced severity of aspirin\u2010related upper gastrointestinal bleeding in older people"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0598-151X","authenticated-orcid":false,"given":"Oyekoya T.","family":"Ayonrinde","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Fiona Stanley Hospital  Perth Western Australia Australia"},{"name":"Medical School The University of Western Australia  Perth Western Australia Australia"},{"name":"Faculty of Health Sciences 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