{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:53:26Z","timestamp":1789016006469,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Double\u2010hit lymphoma (DHL) is an aggressive subtype of high\u2010grade B\u2010cell lymphoma with inferior prognosis using standard dose chemotherapy. Controversy remains whether more intensive chemotherapy regimens such as dose\u2010adjusted etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin and rituximab (DA\u2010EPOCH\u2010R) provide better outcomes in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To review consecutive cases of DHL treated with DA\u2010EPOCH\u2010R at our institution in comparison to available literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective study of 13 consecutive patients with DHL treated with DA\u2010EPOCH\u2010R at our institution. Primary endpoints included complete response (CR), event\u2010free survival (EFS) and overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CR rate with DA\u2010EPOCH\u2010R in DHL was 69% in our cohort. Median EFS and OS duration was 61 months (95% CI: 41\u201386 months) and 64 months (95% CI: 42\u201386 months) respectively. One patient discontinued DA\u2010EPOCH\u2010R due to recurrent febrile neutropenia and there were no treatment or infection\u2010related deaths during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that DA\u2010EPOCH\u2010R is a well tolerated outpatient regimen for DHL and should be considered for initial treatment in medically fit patients. Further prospective studies are warranted to confirm these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15747","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T07:19:48Z","timestamp":1647328788000},"page":"773-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dose\u2010adjusted EPOCH\u2010R is a safe and well tolerated outpatient treatment regimen in double\u2010hit lymphoma"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0246-5691","authenticated-orcid":false,"given":"Ricky","family":"Nelles","sequence":"first","affiliation":[{"name":"Department of Haematology Sunshine Cost University Hospital  Sunshine Coast Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Cancer Care Services Royal Brisbane and Women's 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