{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T13:30:49Z","timestamp":1759411849253,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,10,6]],"date-time":"2022-10-06T00:00:00Z","timestamp":1665014400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous anaphylaxis or immediate allergic reaction to polyethylene glycol (PEG; also known as macrogol) is considered a contraindication to the BNT162b2 mRNA COVID\u201019 vaccine, which contains 50\u2009ug of PEG at a molecular weight of 2000, and this component is thought to account for the higher rate of anaphylaxis seen with this vaccine (4.7 per million doses) than with other non\u2010mRNA vaccines. However, there is evidence that both anaphylaxis to PEG and anaphylaxis to the Pfizer COVID\u201019 reaction may not be IgE\u2010mediated, with patients with anaphylaxis to first dose of the Pfizer COVID\u201019 vaccine receiving their second dose of vaccine without no or milder reactions in a high\u2010risk clinic setting. In New Zealand, non\u2010PEG\u2010containing COVID\u201019 vaccines were not available until late 2021. Therefore, we offered patients with known or suspected PEG anaphylaxis their first dose of Pfizer COVID\u201019 vaccine in a high\u2010risk hospital clinic. Eleven patients with previous hypersensitivity to PEG (including eight with anaphylaxis) successfully received their first dose with mild or no reactions; all have now had their second doses in the community without significant reaction. Record review also showed that most patients with previous hypersensitivity reactions to pegylated asparaginase have also been successfully vaccinated. This demonstrates that previous PEG hypersensitivity, including anaphylaxis, does not exclude immunisation with the Pfizer COVID\u201019 vaccine.<\/jats:p>","DOI":"10.1111\/imj.15821","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T08:48:10Z","timestamp":1661330890000},"page":"1818-1820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Patients with previous immediate hypersensitivity reactions to polyethylene glycol can safely receive the BNT162b2 mRNA COVID\u201019 vaccine"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3084-3039","authenticated-orcid":false,"given":"Miriam","family":"Hurst","sequence":"first","affiliation":[{"name":"Department of Clinical Immunology and Allergy Auckland Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Jordan","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Auckland Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice","family":"Capstick","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Auckland Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maia","family":"Brewerton","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology and Allergy Auckland Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruellyn","family":"Cockroft","sequence":"additional","affiliation":[{"name":"Starship Blood and Cancer Centre Starship Children's Hospital  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Ingram","sequence":"additional","affiliation":[{"name":"The Immunisation Advisory Centre University of Auckland  Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,10,6]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2021.04.002"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.03.002"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1824"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.1967"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14958"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2021.11.006"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.29295"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/imj.15821","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.15821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T02:38:59Z","timestamp":1692671939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.15821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":7,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1111\/imj.15821"],"URL":"https:\/\/doi.org\/10.1111\/imj.15821","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"type":"print","value":"1444-0903"},{"type":"electronic","value":"1445-5994"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"2022-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}