{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:44:41Z","timestamp":1792118681583,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010443","name":"RACP Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Computed tomography\u2010guided transthoracic biopsy (CT\u2010TTB) is the \u2018gold standard\u2019 biopsy for lung nodules. Radial\u2010endobronchial ultrasound (R\u2010EBUS) bronchoscopy is another recommended biopsy but carries a lower diagnostic yield. Addition of cryobiopsy with R\u2010EBUS (Cryo\u2010Radial) has shown promising results. There are no studies comparing CT\u2010TTB with\u00a0Cryo\u2010Radial biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The co\u2010primary aims were the diagnostic yeild and safety. The secondary aim: ability to test epidermal growth factor receptor (EGFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomised controlled, multicentre exploratory study was conducted at three tertiary hospitals. Patients with nodules &gt;1 cm on CT of the chest were randomised to CT\u2010TTB or Cryo\u2010Radial. With Cryo\u2010Radial, patients had 1\u20133 cryo\u2010biopsies in addition to at least one R\u2010EBUS biopsy through the 2.6\u2009mm guide sheath.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight patients were randomised: 22 to CT\u2010TTB and 26 to Cryo\u2010Radial. Sixteen in the CT\u2010TTB and 20 in the Cryo\u2010Radial received the allocated biopsy. The diagnostic yield was CT\u2010TTB 93.8% (15\/16) versus Cryo\u2010Radial 85% (17\/20) <jats:italic>P<\/jats:italic> =\u20090.61 and the odds ratio was 0.37. For 5\/13 (38%), a diagnosis was solely made on cryobiopsy. Eleven (78%) of 14 in CT\u2010TTB versus 7\/10 (70%) Cryo\u2010Radial were suitable for EGFR testing <jats:italic>P<\/jats:italic> =\u20090.66, with odds ratio 0.63. Pneumothorax occurrence was 44% (7\/16) in CT\u2010TTB versus 4.2% (1\/24) in Cryo\u2010Radial. Two (12.5%) of 16 CT\u2010TTB required chest drain insertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cryo\u2010Radial is comparable in diagnostic yield and ability to perform EGFR testing with a significantly lower risk of pneumothorax, compared with\u00a0CT\u2010TTB. Cryo\u2010Radial has the additional advantage of mediastinal staging during the same procedure with Linear\u2010EBUS and is a promising first\u2010line tool in the diagnostic method of lung cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15833","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T12:00:23Z","timestamp":1654689623000},"page":"1390-1399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cryobiopsy with radial\u2010endobronchial ultrasound (Cryo\u2010Radial) has comparable diagnostic yield with higher safety in comparison with computed tomography\u2010guided transthoracic biopsy for peripheral pulmonary lesions: an exploratory randomised study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9669-1066","authenticated-orcid":false,"given":"Samantha","family":"Herath","sequence":"first","affiliation":[{"name":"Northern Beaches 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