{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T16:06:28Z","timestamp":1771603588021,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Magnetic Resonance Imaging is used for evaluation of bone in Gaucher disease (GD), but a widely available quantitative scoring method remains elusive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The study purpose was to assess the reproducibility of the LiverLab tool for assessing bone marrow fat fraction (FF) and determine whether it could differentiate GD patients from healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten healthy volunteers and 18 GD patients were prospectively recruited. FF was calculated at L3, L4 and L5. GD patient bone marrow burden (BMB) score assessed by one observer. Inter and intra\u2010rater agreement assessed with Bland\u2013Altman data plots. Differences in FF between healthy volunteers versus GD patients and between subjects treated versus not treated assessed using two\u2010sample <jats:italic>t<\/jats:italic>\u2010tests. In GD patients, the relationship between FF, BMB and glucosylsphingosine was determined using the Pearson's correlation coefficient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Healthy volunteer mean FF was 0.36, standard deviation (SD) 0.10 (range 0.20\u20130.57). Intra and inter\u2010rater SD were both 0.02. GD patient mean FF was 0.40, SD 0.13 (range 0.09\u20130.57). No statistical difference was shown between healthy volunteers and GD patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.447) or between GD patients whether on enzyme replacement therapy or not (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.090). No significant correlation between mean FF and total BMB (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.525, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.253) or between FF and glucosylsphingosine levels (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.287, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.248).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Excellent reproducibility of LiverLab FF measurements across studies and observers is comparable to Dixon quantitative chemical shift imaging (QCSI). Lack of statistical difference between GD patients and controls may be explained by limited patient numbers, active treatment or mild disease severity in untreated patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15858","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T07:14:37Z","timestamp":1656400477000},"page":"1163-1169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fat fraction quantification of bone marrow in the lumbar spine using the <scp>LiverLab<\/scp> assessment tool in healthy adult volunteers and patients with Gaucher disease"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8766-240X","authenticated-orcid":false,"given":"Calvin","family":"Gan","sequence":"first","affiliation":[{"name":"Department of Radiology, The Royal Melbourne Hospital The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia L.","family":"Robertson","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Royal Melbourne Hospital The University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey K. 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