{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T12:11:17Z","timestamp":1772712677992,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The development of vaccines against SARS\u2010CoV2 has been a key public health response to the COVID\u201019 pandemic. However, since their introduction, there have been reports of anaphylactic reactions to vaccines in individuals with history of allergic reactions to other vaccines, excipients or to COVID vaccines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>A dedicated adult COVID vaccine allergy clinic with a standardised allergy testing protocol was set up to investigate safety and suitability of available COVID vaccines in Australia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients referred to a state\u2010wide COVID\u201019 vaccine allergy clinic between March and August 2021 with a history of allergy underwent skin\u2010prick testing and intradermal testing to both available vaccine formulations (BNT162b2 and ChAdOx1\u2010S), excipients (polyethylene glycol and polysorbate 80), excipient\u2010containing medications and controls. Basophil activation testing was conducted in few subjects with convincing history of immediate type reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three patients underwent testing for possible excipient allergy (<jats:italic>n<\/jats:italic> = 19), previous non\u2013COVID vaccine reaction (<jats:italic>n<\/jats:italic> = 13) or previous reaction to dose 1 of COVID\u201019 vaccine (<jats:italic>n<\/jats:italic> = 21). Patients were predominantly female (<jats:italic>n<\/jats:italic> = 43, 81%), aged 18\u201383 (median 54) years. Forty\u2010four patients tested negative and 42 of these received at least their first dose of a COVID\u201019 vaccine. Nine patients tested positive to excipients or excipient\u2010containing medication only (<jats:italic>n<\/jats:italic> = 3), or vaccines (<jats:italic>n<\/jats:italic> = 6). Five patients were positive to just BNT162b2, 3\/5 have been vaccinated with ChAdOx1\u2010S. One who was skin test positive to both vaccines, but negative BAT to ChAdOx1\u2010S was successfully vaccinated with ChAdOx1\u2010S.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Even in a high\u2010risk population, most patients can be vaccinated with available COVID\u201019 vaccines. This paper reports local experiences using a combined allergy testing protocol with skin testing and BAT during the pandemic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15888","type":"journal-article","created":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T10:39:45Z","timestamp":1658140785000},"page":"1884-1890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["COVID vaccination can be performed in patients with a history of allergic reactions to the vaccines or their components: experience from a specialist clinic in South Australia"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-1008","authenticated-orcid":false,"given":"Matthew","family":"Tunbridge","sequence":"first","affiliation":[{"name":"Immunology Department Royal Adelaide Hospital  Adelaide South Australia Australia"},{"name":"Faculty of Medicine University of Queensland  Brisbane Queensland 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