{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T11:59:45Z","timestamp":1754481585708,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Canterbury, near complete identification of coronavirus disease 2019 (COVID\u201019) cases during a limited outbreak provides unique insights into sequelae.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The current study aimed to measure symptom persistence, time to return to normal activity, generalised anxiety and health\u2010related quality of life (HrQoL) among COVID\u201019 survivors compared with uninfected participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The authors conducted a prospective cohort study of people tested for COVID\u201019 by reverse transcriptase polymerase chain reaction of nasopharyngeal swabs from 1 March to 30 June 2020. They enrolled participants who tested positive and negative at a 1:2 ratio, and administered community\u2010acquired pneumonia, 7\u2010item generalised anxiety disorder (GAD\u20107) and HrQoL (RAND\u201036) questionnaires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The authors recruited 145 participants, 48 with COVID\u201019 and 97 without COVID\u201019. The mean time from COVID\u201019 testing to completing the health questionnaire was 306\u2009days. The mean age of patients was 46.7\u2009years, and 70% were women. Four (8%) COVID\u201019\u2013positive and eight (8%) COVID\u201019\u2013negative participants required hospitalisation. Fatigue (30\/48 [63%] vs 13\/97 [13%]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), dyspnoea (13\/48 [27%] vs 6\/97 [6%]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and chest pain (10\/48 [21%] vs 1\/97 [1%]; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were persistent in those with COVID\u201019. Fewer COVID\u201019\u2013positive participants returned to normal activity levels (35\/48 [73%] vs 94\/97 97%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), with longer times taken (median 21 vs 14\u2009days; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.007). The GAD\u20107 and RAND\u201036 scores of both groups were similar across all anxiety and HrQoL subscales.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Persistent symptoms and longer recovery times were found in COVID\u201019 survivors, but not impaired generalised anxiety levels or HrQoL compared with COVID\u201019\u2013uninfected participants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.15930","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T04:39:40Z","timestamp":1663389580000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Symptom persistence and recovery among COVID\u201019 survivors during a limited outbreak in Canterbury, New Zealand: a prospective cohort study"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9352-3510","authenticated-orcid":false,"given":"Jeanette","family":"Cheung","sequence":"first","affiliation":[{"name":"Respiratory Medicine Department Canterbury District Health Board  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Nordmeier","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department Canterbury District Health Board  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Kelland","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department Canterbury District Health Board  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Harrington","sequence":"additional","affiliation":[{"name":"Microbiology Department Canterbury Health Laboratories  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Williman","sequence":"additional","affiliation":[{"name":"Department of Population Health University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malina","family":"Storer","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department Canterbury District Health Board  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Beaglehole","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Beckert","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department Canterbury District Health Board  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Pathology and Biomedical Sciences University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J","family":"Epton","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department Canterbury District Health Board  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Freeman","sequence":"additional","affiliation":[{"name":"Microbiology Department Canterbury Health Laboratories  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R","family":"Murdoch","sequence":"additional","affiliation":[{"name":"Microbiology Department Canterbury Health Laboratories  Christchurch New Zealand"},{"name":"Department of Pathology and Biomedical Sciences University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja M","family":"Werno","sequence":"additional","affiliation":[{"name":"Microbiology Department Canterbury Health Laboratories  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-1508","authenticated-orcid":false,"given":"Michael J","family":"Maze","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Department Canterbury District Health Board  Christchurch New Zealand"},{"name":"Department of Medicine University of Otago  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32656-8"},{"key":"e_1_2_8_3_1","unstructured":"World Health Organisation Report. 6 October 2021. 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