{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T14:51:15Z","timestamp":1767192675446,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T00:00:00Z","timestamp":1679702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antimicrobial resistance and therapy\u2010related adverse effects make <jats:italic>Mycobacterium abscessus<\/jats:italic> treatment challenging. Omadacycline is a novel, bioavailable aminomethylcycline with favourable <jats:italic>in vitro<\/jats:italic> activity against <jats:italic>M. abscessus<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To describe a case report and review the published literature describing outcomes for <jats:italic>M. abscessus<\/jats:italic> infections treated with omadacycline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified three articles that, in addition to our case report, describe 18 patients. Pulmonary infections were most frequent. Minimum inhibitory concentrations were reported for two isolates (0.25 and 0.5 mg\/L). Despite half the patients starting omadacycline because of failure of prior therapy, 15 (83%) had a favourable outcome, defined as \u2018cure\u2019, \u2018improvement\u2019 or \u2018clinical success\u2019 as determined by the primary study authors. One patient (6%) discontinued omadacycline because of gastrointestinal intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the limited observational data and <jats:italic>in vitro<\/jats:italic> susceptibility results are encouraging, randomised control trials are required to determine the role of omadacycline as part of combination therapy for this most difficult\u2010to\u2010treat pathogen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/imj.16071","type":"journal-article","created":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T15:29:25Z","timestamp":1678807765000},"page":"2257-2263","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Omadacycline therapy for <i>Mycobacterium abscessus<\/i> species infections"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7733-7072","authenticated-orcid":false,"given":"Paul R.","family":"Ingram","sequence":"first","affiliation":[{"name":"Royal Perth Hospital  Perth Western Australia Australia"},{"name":"PathWest Laboratory Medicine  Perth Western Australia Australia"},{"name":"University of Western Australia  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bethwyn","family":"Allen","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronan J.","family":"Murray","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine  Perth Western Australia Australia"},{"name":"University of Western Australia  Perth Western Australia Australia"},{"name":"Sir Charles Gairdner Hospital  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terillee J.","family":"Keehner","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Whitmore","sequence":"additional","affiliation":[{"name":"Royal Perth Hospital  Perth Western Australia Australia"},{"name":"Anita Clayton Centre  Perth Western Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,25]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Utilizing the promise of omadacycline in a resistant, non\u2010tubercular mycobacterial pulmonary infection","volume":"11","author":"Minhas R","year":"2019","journal-title":"Cureus"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01947-20"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaa415"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku062"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00067"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01704-21"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000242"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofab002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01132-13"},{"volume-title":"Performance Standards for Susceptibility Testing of Mycobacteria, Nocardia spp., and Other Aerobic Actinomycetes","year":"2018","author":"CLSI","key":"e_1_2_7_11_1"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.5.1271"},{"key":"e_1_2_7_13_1","first-page":"1225","article-title":"Evaluation of the use of omadacycline in adults with nontuberculous mycobacterium infections","volume":"4","author":"Giang GFP","year":"2021","journal-title":"J Am Coll Clin Pharm"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2021.08.002"},{"key":"e_1_2_7_15_1","article-title":"Mycobacterium abscessus infection in left ventricular assist device (LVAD): a case series","volume":"13","author":"Hernandez JM","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_7_16_1","unstructured":"GuzmanJ Bolender E SabetS MartinK.Multi\u2010Drug ResistantMycobacterium abscessusOsteomyelitis Following an ATV Accident; 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