{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:56:56Z","timestamp":1789394216326,"version":"build-2803163510"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Internal Medicine Journal"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iron deficiency is the most common nutritional deficiency worldwide, with significant adverse health consequences in the presence or absence of anaemia. Total dose intravenous iron replacement is recommended for replacement of iron in patients with severe iron deficiency, especially in the presence of anaemia, intolerance or inefficacy following oral iron, or states of inflammation where upregulation of hepcidin may impair gastrointestinal absorption of iron. Currently, available intravenous iron formulations have been demonstrated to have an excellent overall safety profile, but potential adverse effects, including skin staining, infusion\u2010related reactions and hypophosphataemia, have been described. Knowledge of differences in administration and safety profiles of currently available iron formulations will allow appropriate prescription, counselling, as well as recognition and management of adverse events in patients requiring intravenous iron.<\/jats:p>","DOI":"10.1111\/imj.16184","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T17:38:52Z","timestamp":1690306732000},"page":"26-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Intravenous iron: an update"],"prefix":"10.1111","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-6631","authenticated-orcid":false,"given":"Sarah","family":"Lucas","sequence":"first","affiliation":[{"name":"Northern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9149-3589","authenticated-orcid":false,"given":"Mayur","family":"Garg","sequence":"additional","affiliation":[{"name":"Northern Health  Melbourne Victoria Australia"},{"name":"Department of Medicine University of Melbourne  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"PBS Analytics and Strategic Insight Section Pricing and PBS Policy Branch Technology Assessment and Access Division PBS Expenditure and Prescriptions Report; 2021."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8110693"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32594-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24820"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00116"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-05-786590"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1717"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.103366"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.06.046"},{"key":"e_1_2_9_11_1","unstructured":"World Health Organization.WHO Guideline on Use of Ferritin Concentrations to Assess Iron Status in Individuals and Populations [Internet]. 2020 [cited 2023 Jun 5]. Available from URL:https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK569877\/"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2021-325210"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15739"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2017.03.045"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.761599"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(17)30182-5"},{"key":"e_1_2_9_17_1","unstructured":"Therapeutic Guidelines.Oral Iron Supplementation [Internet]. 2022 [cited 2023 Jun 4]. Available from URL:https:\/\/tgldcdp.tg.org.au.acs.hcn.com.au\/viewTopic?etgAccess=true&guidelinePage=Gastrointestinal&topicfile=c_GIG_Gastro-oesophageal-reflux-in-adultstopic_1&guidelinename=auto&sectionId=c_GIG_Oral-iron-supplementationtopic_2#c_GIG_Oral-iron-supplementation"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14999"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.599080"},{"key":"e_1_2_9_20_1","unstructured":"Therapeutic Guidelines.Intravenous Iron Supplementation [Internet]. 2022 [cited 2023 Jan 17]. Available from URL:https:\/\/tgldcdp.tg.org.au.acs.hcn.com.au\/viewTopic?etgAccess=true&guidelinePage=Gastrointestinal&topicfile=c_GIG_Intravenous-iron-supplementationtopic_1&guidelinename=Gastrointestinal&sectionId=c_GIG_Intravenous-iron-supplementationtopic_1#c_GIG_Intraveno"},{"key":"e_1_2_9_21_1","first-page":"241","article-title":"Management of iron deficiency anemia","volume":"11","author":"Jimenez K","year":"2015","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/hdi.12560"},{"key":"e_1_2_9_23_1","unstructured":"Australian Government Department of Health and Aged Care.The Pharmaceutical Benefits Scheme [Internet]. [cited 2023 Jun 12]. Available from URL:https:\/\/www.pbs.gov.au\/browse\/medicine-listing"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045604"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2010.02356.x"},{"key":"e_1_2_9_26_1","unstructured":"Therapeutic Goods Administration.Venofer (Iron Sucrose) [Internet]. Australian Product Information. 2021 [cited 2023 Jan 19]. Available from URL:https:\/\/www.ebs.tga.gov.au\/ebs\/picmi\/picmirepository.nsf\/pdf?OpenAgent=&id=CP-2013-PI-01566-1&d=20230118172310101&d=20230119172310101&d=20230119172310101"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13805"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25060"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"e_1_2_9_30_1","unstructured":"Therapeutic Goods Administration.Database of Adverse Event Notifications (DAEN) [Internet]. Australian Government Department of Health. 2023 [cited 2023 Apr 11]. Available from URL:www.tga.gov.au\/database-adverse-event-notifications-daen"},{"key":"e_1_2_9_31_1","unstructured":"Medical Board of Australia.Case Study: Iron Infusions \u2013 What Do You Mean This Skin Stain Is Permanent? 2019."},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15837"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12773"},{"key":"e_1_2_9_34_1","first-page":"1660","article-title":"Safety of intravenous iron following infusion reactions","volume":"9","author":"Kar Aung A","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25564"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90463-1"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.57"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13268"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2009.01898.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.11.028"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018816678363"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14643"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01770-2"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jppr.1791"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1923"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01643-5"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116202"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16075"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajag.12776"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321667"},{"key":"e_1_2_9_52_1","article-title":"Parenteral versus oral iron therapy for adults and children with chronic kidney disease","volume":"2019","author":"Olone EL","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002308"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2017.1351239"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hft083"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq158"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02083-9"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496492"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318484"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.03146.x"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MIB.0000196646.64615.db"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mib.0000235097.86360.04"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jju009"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16221"},{"key":"e_1_2_9_66_1","unstructured":"The World Health Organization.Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity; 2011."},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13870"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16184","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T03:15:02Z","timestamp":1706152502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16184"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,25]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1111\/imj.16184"],"URL":"https:\/\/doi.org\/10.1111\/imj.16184","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"value":"1444-0903","type":"print"},{"value":"1445-5994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,25]]},"assertion":[{"value":"2023-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}