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It is generally estimated to affect 10\u201330% of those diagnosed with hypertension, though the true incidence might be lower after one factor in the prevalence of non\u2010adherence. Risk factors for its development include diabetes, obesity and other adverse lifestyle factors, and a diagnosis of RHT confers a greater risk of adverse cardiovascular outcomes, such as stroke, heart failure and mortality. It is essential to exclude pseudoresistance and secondary hypertension and to ensure non\u2010pharmacologic management is optimised prior to consideration of fourth\u2010line anti\u2010hypertensive agents or advanced interventions, such as device therapies. In this review, we will cover the different definitions of RHT, along with the importance of careful diagnosis and management strategies, and discuss newer agents and research needs.<\/jats:p>","DOI":"10.1111\/imj.16189","type":"journal-article","created":{"date-parts":[[2023,7,26]],"date-time":"2023-07-26T13:02:26Z","timestamp":1690376546000},"page":"1739-1751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Revisiting resistant hypertension: a comprehensive review"],"prefix":"10.1111","volume":"53","author":[{"given":"Ryan J.","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine University of Ottawa and the Ottawa Hospital  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wryan","family":"Helmeczi","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Ottawa  Ottawa Ontario 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