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Penicillin allergy de\u2010labelling improves healthcare outcomes; however, less attention is paid to modifying risk factors leading to penicillin allergy development. In this propensity score\u2010matched retrospective cohort study, we used a de\u2010identified population\u2010based database (TriNetX Research Network) and examined the 30\u2010day risk of acquiring a penicillin allergy label in patients using proton pump inhibitors (PPIs). We demonstrated a higher risk of acquiring a penicillin allergy label among PPI users compared to controls.<\/jats:p>","DOI":"10.1111\/imj.16197","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T07:05:55Z","timestamp":1691391955000},"page":"1481-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proton pump inhibitors and the risk of acquiring a penicillin allergy label"],"prefix":"10.1111","volume":"53","author":[{"given":"Sarah","family":"Al\u2010Obaydi","sequence":"first","affiliation":[{"name":"Department of Medicine, Penn State College of Medicine Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Popadiuk","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy &amp; Critical Care, Department of Medicine, Penn State College of Medicine Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-8937","authenticated-orcid":false,"given":"Taha","family":"Al\u2010Shaikhly","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Allergy &amp; Critical Care, Department of Medicine, Penn State College of Medicine Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.08.028"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2010.08.002"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i22.2706"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01584"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12103"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12034"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3170fje"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03363.x"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.18.2819"},{"key":"e_1_2_4_11_1","first-page":"20","article-title":"Routine penicillin skin testing in hospitalized patients with a history of penicillin allergy","volume":"8","author":"Macy E","year":"2004","journal-title":"Perm J"}],"container-title":["Internal Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/imj.16197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T12:43:16Z","timestamp":1752756196000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/imj.16197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":10,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/imj.16197"],"URL":"https:\/\/doi.org\/10.1111\/imj.16197","archive":["Portico"],"relation":{},"ISSN":["1444-0903","1445-5994"],"issn-type":[{"type":"print","value":"1444-0903"},{"type":"electronic","value":"1445-5994"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}