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Studies examining the relationship between baseline PROs and prognosis were included. Two reviewers independently screened articles and extracted data on study design, survival and associations between PROs and survival, in both univariable and multivariable analyses. QUIPS was used for quality assessment. From 3004 studies screened, seven studies were eligible, comprising PRO data from 2761 of 3408 (81%) participants. Median survival times ranged from 4.5 to 9.5 months. Among participants with oesophageal squamous cell carcinoma (SCC), physical functioning, social functioning and fatigue (QLQ\u2010C30) were associated with overall survival (OS) in one univariable analysis. Among three studies of participants with adenocarcinoma, univariable analyses revealed associations between OS and global quality of life (QOL), physical functioning, role functioning and social functioning; two studies showed association with pain. There was an association between emotional functioning, fatigue, lack of mobility, lack of self\u2010care, appetite loss\/anorexia and OS in one study. One multivariable analysis among participants with oesophageal SCC showed physical and social functioning was associated with OS. Among participants with adenocarcinoma, multivariable analyses showed associations between OS and physical functioning\/lack of mobility, appetite loss\/anorexia (three studies), global QOL, role functioning\/lack of self\u2010care, pain (two studies) and social functioning (one study). Physical functioning, role functioning, social functioning, pain, anorexia and global QOL were associated with OS in advanced GO cancer.<\/jats:p>","DOI":"10.1111\/imj.16209","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:18:57Z","timestamp":1692695937000},"page":"1946-1955","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic value of patient reported outcomes in advanced gastro\u2010oesophageal cancer: a systematic review"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9540-2760","authenticated-orcid":false,"given":"Sayeda K.","family":"Naher","sequence":"first","affiliation":[{"name":"National Health and Medical Research Council (NHMRC) Clinical Trials Centre (CTC) University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Mercieca\u2010Bebber","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council (NHMRC) Clinical Trials Centre (CTC) University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derrick","family":"Siu","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council (NHMRC) Clinical Trials Centre (CTC) University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Grimison","sequence":"additional","affiliation":[{"name":"Medical Oncology Chris O'Brien Lifehouse  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Stockler","sequence":"additional","affiliation":[{"name":"National Health and Medical Research Council (NHMRC) Clinical Trials Centre (CTC) University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_7_3_1","article-title":"Chemotherapy for advanced gastric cancer","volume":"8","author":"Wagner DA","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_4_1","article-title":"Chemotherapy for advanced gastric cancer","volume":"3","author":"Wagner AD","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.3370"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00797-2"},{"key":"e_1_2_7_7_1","first-page":"12","article-title":"Quality of life during palliative systemic therapy for Esophagogastric cancer: systematic review and meta\u2010analysis","volume":"112","author":"Kleef JJ","year":"2020","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2014-0058"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016692804023"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.04.095"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269216308098799"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo.2017.11.08"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl501"},{"key":"e_1_2_7_14_1","article-title":"Prognostic value of neutrophil to lymphocyte ratio for gastric cancer","volume":"3","author":"Hu Z\u2010D","year":"2015","journal-title":"Ann Transl Med"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.39575"},{"key":"e_1_2_7_16_1","unstructured":"U.S. Department of Health and Human Services FDA Center for Drug Evaluation and Research; U.S. Department of Health and Human Services FDA Center for Biologics Evaluation and Research; U.S. Department of Health and Human Services FDA Center for Devices and Radiological Health.Guidance for Industry Patient\u2010Reported Outcome Measures: Use in Medical Product Development to Support Labeling Claims. 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