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We report our experience using BLM in three cases of refractory lupus nephritis (LN), where renal remission was not achieved using cyclophosphamide, mycophenolate\u00a0mofetil and other immunosuppressive medications. In two of the three cases, BLM therapy led to a partial remission of LN, improvement in serological markers of SLE and disease activity, which permitted a reduction in prednisolone dosing. Treatment with efficacious therapies early in the course of LN is a desirable therapeutic strategy, to achieve early remission of proteinuria and curtail the development of irreversible chronic renal damage. Further studies are needed to provide information on the effectiveness of BLM for maintenance of remission, prevention of flares and monitoring for long\u2010term complications of B\u2010cell modulation.<\/jats:p>","DOI":"10.1111\/imj.16242","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T06:28:08Z","timestamp":1697783288000},"page":"1901-1906","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The use of belimumab in three cases of refractory lupus nephritis"],"prefix":"10.1111","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2807-2420","authenticated-orcid":false,"given":"Aruni","family":"Malaweera","sequence":"first","affiliation":[{"name":"Department of Nephrology Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukhpal","family":"Dayan","sequence":"additional","affiliation":[{"name":"Department of 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